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Staff Scientist, Bioinformatics

Nautilus Biotechnology
San Carlos, CA Full Time
POSTED ON 11/18/2025 CLOSED ON 12/17/2025

What are the responsibilities and job description for the Staff Scientist, Bioinformatics position at Nautilus Biotechnology?

At Nautilus, we have a big and important mission: to improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are looking for a Staff Scientist to join our Bioinformatics team and play a key role in supporting our early access program for proteomics analysis. In this role, you will work closely with early users of our technology - helping them to design experiments, troubleshoot problems as they arise, and interpret results - ensuring our customers gain the most insight from our platform. Additionally, you will relay critical feedback from customers to our internal development team to support platform improvements. The ideal candidate will have a strong background in biology and a deep understanding of how proteomics can be applied in scientific and clinical contexts.

Responsibilities

  • Catalyze the success of our earliest customers by deeply understanding their scientific goals and ensuring a smooth and productive experience with our platform.
  • Be the bioinformatics leader on multiple (5 ) customer-facing projects, managing relationships and delivering support during our upcoming early access program.
  • Engage with customers in project planning and experimental design to ensure they are positioned for success and understand the capabilities of our platform.
  • Oversee and conduct bioinformatics analyses for our customers including analyzing proteomics data, troubleshooting unexpected results, building visualizations and analyses, and crafting clear presentations.
  • Collaborate cross-functionally with our internal R&D team by relaying scientific feedback from customers to support ongoing platform development.
  • Manage project timelines and deliverables for customer-facing analyses.

Requirements

  • A passion for biology and a commitment to delivering exceptional customer experience.
  • PhD in Bioinformatics, Computational Biology, Biochemistry, or related field with 10 years of experience, or a Master’s degree and 15 years of experience in academic/industry settings.
  • Demonstrated ability to conceive and execute novel experimental design, applying bioinformatics methods to address complex biological questions.
  • Ability to communicate technical content clearly and effectively, including to audiences without a bioinformatics background
  • Proficiency with Python and common scientific libraries such as numpy, pandas, scipy, and matplotlib.
  • Experience with version control and the Github ecosystem.
  • Familiarity with cloud computing (e.g. AWS) and relational databases (e.g. SQL) (preferred).
  • Experience working with proteomics data (preferred).
  • Experience with project leadership or strategic/alliance partnerships with pharmaceutical or academic collaborators (preferred).

Nautilus Team Culture

  • We are determined to do whatever it takes to get our platform into the hands of researchers who will use it to upend the status quo in basic research and healthcare.
  • We work on cross functional teams, wear many hats, take risks to work through uncertainty, enjoy working collaboratively on challenging problems, and celebrate one another’s victories.
  • We go above and beyond, but also strive to provide a supportive atmosphere of colleagues who are willing to lend a helping hand and make working at Nautilus not only fulfilling in its end goals, but enjoyable on a day-to-day basis.

Compensation Range: $145K - $196K

Salary : $145,000 - $196,000

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