Scientist (Mass Spectrometry)

POSITION SUMMARY

We are seeking a highly motivated Postdoctoral Scientist with expertise in mass spectrometry-based metabolomics and biomarker discovery, collaborating with the Stanford University translational medicine laboratory. The ideal candidate will have strong experience in compound identification, metabolomics/lipidomics, as well as in linking metabolism to disease biology. This role will involve developing and optimizing advanced Thermal Fisher platform LC-MS workflows, applying both global and targeted analytical techniques, and collaborating with cross-functional teams to drive discovery and validation of clinically relevant biomarkers.

ESSENTIAL FUNCTIONS

• Design and execute metabolomics, lipidomics, and proteomics studies to support compound discovery, compound identification, compound PRM/MRM quantification, and biomarker development.
• Develop and implement advanced LC-MS workflows (including HILIC/RP LCMS/MS, and global/targeted metabolomics assays) for compound separation, characterization, and quantitative molecular profiling of clinical samples (tissue, serum, plasma).
• Perform method development, troubleshooting, and optimization (rephrase/validation phases) to improve sensitivity, specificity, and robustness of clinical assays.
• Conduct targeted and untargeted metabolite/lipid searches to uncover and quantify metabolic pathway alterations and integrate findings with biological insights to link metabolism with disease.
• Operate and maintain mass spectrometry platforms (Quadrupole-Orbitrap, Triple-Quadrupole, uHPLC, and nano-LC) in research and later GLP/CLIA-regulated environments.
• Evaluate emerging technologies and integrate them into the discovery pipeline to enhance throughput, data quality, and translational impact.
• Collaborate with both academia and industry groups (Molecular Oncology, Mass Spectrometry, Genomics) and external pharma partners to advance preclinical and clinical research initiatives.
• Utilize ELISA, qPCR, and complementary molecular biology methods to validate candidate biomarkers.
• Develop, author, and maintain SOPs to ensure compliance with GLP and later CLIA standards.
• Present research findings to internal stakeholders; contribute to publications, regulatory documentation, and patent applications.

EDUCATION/EXPERIENCE REQUIREMENTS

• Ph.D. in analytical chemistry, biochemistry or related field with 0-5 years of post-doctoral experience.
• Strong fundamental knowledge of protein chemistry and understanding of biology of genomic alternations with proteomic phenotype.
• Solid LC-MS background and expertise in metabolomics/lipidomics/proteomics methodologies. Hands-on experience with Quadrupole-Orbitrap mass spectrometry, nano-LC fluidics, and data processing with various software. Experience with PRM/SRM and DDA/DIA.

REQUIRED COMPETENCIES – KNOWLEDGE, SKILLS, ABILITIES

• Problem solving skills based on understanding of raw-data.
• Experience with large-scale data analysis and bioinformatics.
• Excellent oral and written communication skills Passion for science and innovation

WORKING ENVIRONMENT/PHYSICAL REQUIREMENTS

This position requires the employee to work in a laboratory environment at Stanford University, which can create the potential for occupational exposure to biological or chemical hazards.

Job Type: Full-time

Pay: $63,850.42 - $76,895.13 per year

Work Location: In person

Salary : $63,850 - $76,895