Associate Scientist, Postdoctoral Fellow - Quantitative Biosciences

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Postdoctoral Fellow, Quantitative Biosciences (in vitro pharmacology)

Location: Boston, MA

Summary: We are seeking a highly motivated Postdoctoral Fellow to join our Quantitative Biosciences team to develop physiologically relevant in vitro models to investigate the MoA of novel immunotherapies for inflammatory diseases. The role will focus on assay development using human intestinal organoids and primary immune cells. The Postdoctoral Fellow will design and implement the in vitro models to assess potency, mechanism of action, and combination effects of therapeutic candidates.

Key responsibilities

• Develop co-culture and functional assays to measure the crosstalk between intestinal epithelial cells and immune cells.

• Design experiments to profile biologics and small molecules across target panels and immune cell subsets.

• Understand the pharmacology and mechanism of action of therapeutic targets in human intestinal organoids and primary immune cells.

• Confirm findings in orthogonal assays with engineered cell lines and other molecular biology approaches and transcriptomics studies.

• Independently design, plan, execute, and interpret assay data.

• Maintain detailed experimental records.

• Present the research work at internal and external meetings and publish in high-impact journals.

Required qualifications

• Hold a Ph.D. or Ph.D. completed within 6 months of hire in Immunology, Cell Biology, or a related discipline, with a proven track record of first-author publications.

• Demonstrated ability to design, execute, and interpret complex biological experiments.

• Hands-on experience in cell culture, immune cell isolation and differentiation, and human intestinal organoid models.

• Strong skills in flow cytometry, ELISA/our company, cytokine multiplex assays, and cell-based functional assays.

• Experience with dose response analysis and standard pharmacology metrics.

• Strong written and verbal communication skills and ability to work effectively in cross-functional teams.

Preferred Qualifications:

• Prior experience in research related to IBD pathogenesis, mucosal immunology, and T cell biology

• Experience with immunofluorescence, immunohistochemical staining, and/or high-content imaging

postdoctoralopportunities   

Required Skills:

Accountability, Accountability, Adaptability, Analytical Chemistry, Assay Development, Cell-Based Assays, Cell Cultures, Cell Culture Techniques, Computational Biology, Cytokines, Data Analysis, Flow Cytometry, Immunoassays, Immunochemistry, Immunofluorescence Microscopy, Immunology, Immunotherapy, In Vivo Mouse Models, Mammalian Cell Culture, Mathematical Biology, Molecular Biology, Parasitology, Primary Cell Culture, Programming Languages, Scientific Research { 3 more}

Preferred Skills:

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Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

11/25/2025

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R371630