Research Scientist I - Biophysics Department

Summary

The Department of Biophysics at the Medical College of Wisconsin is seeking a highly motivated Research Scientist to join our research team focused on the structural and functional analysis of oncogenic noncoding RNAs. We utilize a multidisciplinary approach that integrates biochemical, biophysical, and structural biology techniques—including NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy—to explore RNA structure–function relationships and identify opportunities for RNA-targeted therapeutic intervention in cancer and related diseases.

This position offers an exciting opportunity for candidates passionate about cutting-edge RNA biology and structural biology, with the potential to develop novel experimental approaches and lead research projects in a collaborative and well-resourced environment

Primary Responsibilities

• Design and execute experiments to investigate the structure and dynamics of noncoding RNAs using biophysical and structural techniques (e.g., NMR, X-ray crystallography, cryo-EM)
• Conduct biochemical assays to study RNA-protein and RNA-small molecule interactions
• Perform in vitro transcription, RNA purification, labeling, and structural probing
• Analyze experimental data, interpret results, and contribute to manuscript preparation
• Present research findings at lab meetings, institutional seminars, and scientific conferences
• Mentor graduate students and contribute to training and scientific development within the lab
• Assist with the development of grant proposals and collaborative research initiatives
• Coordinate research study activities; lead and manage projects.
• May oversee the work of laboratory personnel, including training and development as well as daily work direction/delegation/prioritizing.
• Other duties as assigned.
  
  

Knowledge – Skills – Abilities

• Knowledge of structural biology, protein expression and purification, and molecular biology.
• Structural biology software: Phenix, Coot, Chimera, CryoSPARC, Relion
• Data utilization, complex problem solving, critical thinking, resource management, and writing skills
• Hands-on experience in X-ray crystallography or cryo-EM
• Experience in small molecule drug discovery and structure-based drug design
• Proven ability to work independently, manage time effectively, and troubleshoot experiments
• Excellent written and verbal communication skills
  
  

Qualifications

Appropriate experience may be substituted for education on an equivalent basis.

Minimum Required Education: PhD in a scientific field - in Biochemistry, Biophysics, Structural Biology, Chemistry, Molecular

Minimum Required Experience

Preferred Experience: 5 years of research experience

• Experience in protein expression, purification, and RNA–protein complex reconstitution
• Exposure to small-molecule screening and
• medicinal chemistry
• Strong publication record in peer-reviewed journals
  
  

Physical Requirements

Work requires occasionally lifting moderate weight materials, standing, or walking continuously.

Work Environment

Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.

Sensory Acuity

Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.

Why MCW?

• Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
• 403B Retirement Package
• Competitive Vacation and Paid Holidays offered
• Tuition Reimbursement
• Paid Parental Leave
• Employee & Family Assistance Program (EFAP)
• Pet Insurance
• On campus Fitness Facility, offering onsite classes
• Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.
  
  

For a brief overview of our benefits see: Benefits Overview

For a full list of positions see: MCW Careers

At MCW all of our endeavors, from our internal operations to our interactions with our partners, are driven by our shared organizational values: Caring – Collaborative – Curiosity – Inclusive – Integrity – Respect. We are committed to fostering an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we recognize that a healthy and thriving community starts from within. Our values define who we are, what we stand for and how we conduct ourselves at MCW. If you believe in embracing individuality and working together according to these principles to improve health for all, then MCW is the place for you. For more information, please visit our institutional website.

MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination:

The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.