Research Intern - Cardiology-Research

The research intern will receive comprehensive training in cutting-edge multi-omics methodologies, beginning with tissue macroarray (TMA) preparation and progressing through advanced techniques such as imaging mass cytometry, COMET proteomics, spatial metabolomics, and spatial transcriptomics. The intern will gain hands-on experience in both experimental procedures and data analysis. A key component of the training involves learning to integrate and interpret high-dimensional datasets using AI-based tools, particularly the OmiCLIP2 framework developed by Dr. Guangyu Wang. This model links tissue morphology with molecular states and enables deep insights into cellular organization and tissue microenvironments. The intern will also participate in a translational research project focused on immune checkpoint inhibitor (ICI)-associated myocarditis, contributing to the identification of molecular signatures predictive of clinical outcomes.

All duties and responsibilities are carried out in compliance with institutional policies, ethical research standards, and applicable federal and state regulations.

LEARNING OBJECTIVES

• Understanding Cardio-Oncology Concepts and Mechanisms-
  
  

Students will begin by exploring the pathophysiology of cardiovascular diseases associated with cancer treatments, gaining insights into their clinical relevance and impact on patient outcomes. A significant focus will be placed on understanding cancer therapy-induced premature senescence, emphasizing its molecular mechanisms and long-term implications. Through these sessions, students will develop a nuanced perspective on the interplay between oncology treatments and cardiovascular health, positioning them to contribute to innovative research and therapeutic strategies.

• Laboratory-Based Training and Research Activities-
  
  

Hands-on laboratory experience will be a cornerstone of the program. Students will actively participate in morning sessions and lab meetings to engage with peers and mentors, fostering a collaborative research environment. Daily one-on-one meetings will ensure personalized guidance and progress tracking, enhancing their learning experience. Participants will gain proficiency in advanced laboratory techniques, including Western blotting, histology analysis, imaging cytometry, COMET assay, spatial transcriptomics, proteomics, metabolomics, and confocal microscopy. Each technique is chosen to provide a comprehensive toolkit for investigating cancer therapy-mediated cardiovascular effects at both molecular and cellular levels.

Immersive Learning and Skill Development-

• The program offers extensive learning opportunities tailored to develop students' technical and analytical expertise. By working on imaging, histological, and physiological assessments related to cancer therapy-induced cardiovascular diseases, students will acquire practical skills essential for high-impact research. These hands-on experiences will not only solidify their understanding of cardio-oncology concepts but also prepare them to address broader challenges in translational medicine and biomedical research.
  
  

Eligibility Requirements

• Completion of a Master's degree (MS) or higher in a relevant scientific field
• Demonstrated interest in biomedical research, computational biology, or translational medicine
• Prior laboratory experience and familiarity with molecular biology techniques preferred
• Strong motivation to learn and contribute to high-impact, interdisciplinary research
• Ability to work collaboratively in a multidisciplinary team environment
  
  

POSITION INFORMATION