What are the responsibilities and job description for the Senior Medical Director position at Maze Therapeutics?
The Opportunity
Lead strategy. Drive innovation. Transform lives.
Maze Therapeutics is seeking a Senior Medical Director to lead the clinical development strategy for our APOL1 program, an innovative approach targeting a key genetic driver of chronic kidney disease. In this highly visible leadership role, you will design and oversee early-stage trials, guide cross-functional teams, and ensure alignment with Maze’s mission to deliver transformative medicines.
You’ll engage with scientific thought leaders, patient advocacy groups, and global stakeholders to shape development plans and accelerate progress. This is an opportunity to combine your medical expertise with strategic vision to make a lasting impact on patients living with kidney disease.
In addition to our APOL1 program, Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases, including a second precision medicine for kidney disease that is following closely behind APOL1. This role offers the opportunity to play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.
This position reports to the Head of Clinical Development.
The Impact You’ll Have
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $338,000 to $412,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
Lead strategy. Drive innovation. Transform lives.
Maze Therapeutics is seeking a Senior Medical Director to lead the clinical development strategy for our APOL1 program, an innovative approach targeting a key genetic driver of chronic kidney disease. In this highly visible leadership role, you will design and oversee early-stage trials, guide cross-functional teams, and ensure alignment with Maze’s mission to deliver transformative medicines.
You’ll engage with scientific thought leaders, patient advocacy groups, and global stakeholders to shape development plans and accelerate progress. This is an opportunity to combine your medical expertise with strategic vision to make a lasting impact on patients living with kidney disease.
In addition to our APOL1 program, Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases, including a second precision medicine for kidney disease that is following closely behind APOL1. This role offers the opportunity to play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.
This position reports to the Head of Clinical Development.
The Impact You’ll Have
- Lead the design, execution, and analysis of clinical trials for the APOL1 program and other early-stage clinical assets at Maze
- Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs
- Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators.
- Engage with scientific thought leaders and patient advocacy groups to gain insights to inform clinical development plans and build awareness and enthusiasm for the Maze pipeline assets.
- Partner with Clinical Development Operations to identify and select study investigators and sites and build strong professional relationships with study investigators.
- Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs.
- Develop and integrate timelines and budgets for clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders.
- Communication and Influence
- Role models clear communication and open two-way conversations.
- Reinforces an environment where people feel heard and their opinions are valued.
- Inspires followership despite differing initial opinions.
- Teamwork and Collaboration
- Champions collaboration and connection across Maze.
- Establishes team norms and expectations.
- Seeks opportunities to spotlight team and individual contributions in public forums.
- Execution and Results
- Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success.
- Coaches others on resource management and work distribution/delegation.
- Aligns work to Maze’s strategy mission and vision.
- Develop Others and Self
- Develops staff capabilities to handle delegation of responsibilities.
- Encourages staff to develop and execute personal stretch goals.
- Identifies and recommends ways to increase inclusive leadership.
- MD with 6 years of drug development industry experience.
- Board eligibility/certification and clinical experience in internal medicine and/or pediatrics. Additional clinical or research experience in nephrology or cardiometabolic diseases is preferred.
- Experience as a clinical study medical monitor
- Experience with the preparation and submission of scientific publications, study protocols, Investigator Brochures, and other clinical-regulatory documents.
- Experience in the planning and oversight of early-stage and/or registration-enabling clinical development programs including CRO and site selection and relationship building with investigators/site study staff, patient advocacy groups, and other third parties
- Demonstrated knowledge and experience in the design and conduct of clinical trials and clinical data analysis and interpretation, particularly Phase 2 trials.
- Experience leading a cross-functional study team.
- Committed to nurturing relationships with investigators, site study staff, patient advocacy groups, and other third parties to support the clinical programs and broader Maze objectives.
- Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high-quality data on time and within budget.
- A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals.
- Willingness to travel domestically and internationally (up to 20%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings.
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is $338,000 to $412,000. Additionally, this position is eligible for an annual performance bonus.
Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.
Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.
Salary : $338,000 - $412,000