What are the responsibilities and job description for the Senior Research Technician RNA Synthesis position at Mass General Brigham?
Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
GENERAL SUMMARY / OVERVIEW:The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system. The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.
We are a motivated and technically proficient Senior Research Technician to join our RNA Therapeutics Core (RTC) team and participate in the development of novel RNA-based medicines and technologies. With guidance from senior scientific staff, the candidate who fills this role will develop RNA synthesis, purification, and analytical methods, and produce high quality RNA preparations for experimental applications and external parties. In addition to bench responsibilities, the individual will assist in day-to-day lab operations, including inventory management, equipment maintenance, and implementation of safety protocols. The successful candidate will have experience working in a research laboratory environment and be proficient in standard molecular biology techniques such as cloning, PCR, and electrophoresis. They would preferably have hands-on RNA synthesis experience, be detail-oriented and organized, and eager to work in a team environment.
Qualifications
QUALIFICATIONS :
Bachelor's degree in life sciences, biochemistry, or chemistry with at least 3 years of experience in a laboratory setting
Good organizational skills, detail oriented
Reproducibility of work with accuracy
Sound degree of computer literacy
Ability to methodically record data
Good interpersonal and communication skills
Ability to demonstrate professionalism
Dedication to excellence
PREFERRED COMPETENCIES:
Experience working with mRNA, circular RNA, or long-noncoding RNA
Experience with in vitro transcription and purification processes
Experience with RNA process development
Experience with lab management practice
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Perform a variety of routine procedures following established methodologies including in vitro transcription, silica purification, tangential flow filtration, HPLC, cloning, gel electrophoresis, plasmid outgrowth and purification
Perform analytical techniques and record quality metrics, with a strong focus on accuracy and reproducibility in work
With supervision, develop new processes for RNA synthesis and purification, and implement these processes on automation platforms
Operate laboratory equipment, instruments and robotics to perform repetitive laboratory techniques; learn how to use new instruments
Use universal safety precautions and proper personal protective equipment to protect self and co-workers from biohazardous materials; complete requisite trainings as appropriate
Develop, implement, and enforce laboratory safety protocols in accordance with institutional and regulatory requirements (e.g., OSHA, IBC, EH&S).
Coordinate lab staff training in biosafety, chemical hygiene, and emergency procedures. Serve as the liaison with Environmental Health & Safety (EH&S) and Biosafety Offices for inspections, compliance documentation, and hazard mitigation.
Oversee and maintain accurate inventory of reagents and lab supplies. Coordinate ordering, shipping, receiving, and documentation of laboratory supplies and capital equipment
Participate in lab meetings and generate ideas for improving efficiency and productivity in the lab’s operations
Communicate effectively with the team, discuss progress, and share data with supervisors
All other duties as assigned
Additional Job Details (if applicable)
Remote Type
Work Location
Scheduled Weekly Hours
Employee Type
Work Shift
EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
