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Research Scientist & Antibody Computational Analysis

Mass General Brigham
Cambridge, MA Full Time
POSTED ON 12/18/2025
AVAILABLE BEFORE 1/16/2026
Site: The General Hospital Corporation

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

The DeKosky Laboratory for Immune Engineering and Drug Discovery (www.dekoskylab.org, Google Scholar: http://scholar.google.com/citations?user=z6TwVlwAAAAJ&hl=en) is hiring a scientist to advance computational drug design and discovery, including the use of artificial intelligence (AI) and machine learning (ML) techniques.

The hired candidate will focus on computational aspects of immune repertoire analyses of antibody functional screening data. These efforts will advance methods for rapid machine learning-based antibody drug design while developing new and improved antibody drug products. We are looking for enthusiastic individuals that are curious about computational drug discovery and immunology, and want to participate in the exciting world of diving deeply into understanding how computational data and molecular design can be applied to discovery new drugs and fight diseases. The selected candidate will join a dynamic research team at the forefront of antibody engineering. These projects are fully funded by the several organizations, including the US National Institutes of Health and collaborative projects with the Bill and Melinda Gates Foundation, with several ongoing efforts and new projects ready to begin.

The Ragon Institute is an internationally renowned immunology-focused research center located in Kendall Square, Cambridge, Massachusetts, and with affiliations with MGH, Harvard, and MIT. This position is ideal for individuals who are interested in launching a career as biomedical research leaders in either academia or industry. Successful candidates will be immersed in a rich scientific community and become experts in advanced high-throughput drug development and establish cutting-edge drug screening approaches while being a part of a supportive, highly collaborative research environment with state-of-the-art facilities. The hired candidate will also be an affiliate of MIT, with access to MIT campus research resources and community facilities.

Job Summary

In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary.

Does this position require Patient Care? No

Essential Functions

  • Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field.
  • Contributes to the design and execution of experiments and/or research projects.
  • Exercises judgment in selecting methods and technologies to obtain results.
  • May collaborate with external researchers and/or receive external project funding support.
  • Presents results and prepares publications.
  • May assist PI in the training and supervision of other staff.

Qualifications

Education

Doctorate Related Field of Study required

Can this role accept experience in lieu of a degree? No

Licenses and Credentials

Experience

Previous Research experience (inclusive of graduate and postdoctoral experience) 5-7 years required

Knowledge, Skills And Abilities

  • Excellent research skills.
  • Demonstrated evidence of specific scientific competence in field.
  • Demonstrated broad knowledge of field.
  • Evidence of potential for scientific creativity and original though.
  • Able to exercise independent judgment and leadership.
  • Ability to contribute to publications.

Additional Job Details (if Applicable)

The salary range for this position is 80,000.00 to $105,000.00 annually.

At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience, if applicable, education, certifications, and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package.

In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums, and bonuses as applicable, and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

Remote Type

Onsite

Work Location

600 Main Street

Scheduled Weekly Hours

40

Employee Type

Regular

Work Shift

Day (United States of America)

EEO Statement

The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Salary : $80,000 - $105,000

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