Sr Scientist, In Vivo Pharmacology

Marengo Therapeutics is seeking an experienced and highly motivated In vivo Pharmacologist to join our Immunology research team. As a member of Marengo’s Immunology research team, you will contribute to the characterization of novel T cell-engagers by driving in vivo pharmacological studies towards the identification of clinical candidates.

Roles and responsibilities:

• Design, hands-on execution and interpretation of a wide variety of In vivo pharmacological studies (PK, PD, efficacy, antigen-driven biodistribution, biomarker discovery) to assess drug exposure, target engagement and anti-tumor activity, drug mechanism of action, and biomarker identification
• Contribute to in vivo pharmacology study ideation, optimization, and derive actionable biological conclusions and bring new experimental proposals
• Excellent record keeping of experimental data and results and maintain a current and accurate electronic notebook (ELN)
• Ability to drive and work effectively within cross-functional teams, in a matrix environment, and implement critical studies to deliver lead/drug candidates to key inflection points
• Effective teamwork and engagement with broader project teams to advance portfolio projects
• Provide ideas and perform research to identify and explore new opportunities, developing immune-mediated therapeutics, including continued evolution of the in vivo pharmacology platform at Marengo
• Accountability for developing a clear, fully resourced plan for project progression and delivering to agreed timelines
• Contribute to scientific literature through publication and presentation of research results
• Authoring of documents relevant to regulatory submissions
• Manage relationships with off-site vivarium and maintain animal protocols up-to-date

Qualifications and Education Requirements:

• PhD with 5 years or MS with 8 years of directly relevant pharmaceutical/biotech industry experience in the field of cancer immunology, T cell biology, and/or immuno-oncology, or related discipline with focus on in vivo pharmacology
• Scientific expertise in in vivo models related to immuno-oncology/oncology, such as murine tumor xenograft, syngeneic, or patient-derived xenograft models
• Deep understanding of biologics drug discovery and early-stage drug development as it relates to building a pharmacology package for candidate drug nomination

Required Skills:

• Demonstrated experience developing humanized mouse models for oncology platforms
• Demonstrated experience in designing and executing PK, PK/PD, biodistribution, efficacy, and mechanistic in vivo studies, especially in murine syngeneic tumor models
• Demonstrated experience in generating required in vivo data sets to facilitate drug candidate nomination
• Ability to present projects to internal and external teams for project decisions and inflection points
• Excellent verbal, interpersonal, and written communication skills
• Ability to synthesize complex scientific problems into a clear strategy and tactics
• Detail-oriented with excellent record-keeping and organizational skills
• Highly flexible, results-oriented, independent self-starter who enjoys working in a fast-paced, dynamic environment
• Expertise with diverse molecular and cell biology techniques, including ELISA, multiplex cytokine assays, flow cytometry or IHC is a plus
• Familiarity with Studylog is preferred