What are the responsibilities and job description for the Computational Biologist (Genomics & Variant Interpretation) position at Lifecode?
About Lifecode
Lifecode is a direct-to-consumer whole genome sequencing company. We sequence your entire genome and turn it into personal wellness insights you can actually use. We're a small founding team and we're building the data and interpretation engine that makes 3 billion base pairs meaningful to a regular person.
The role
You'll be our first dedicated genomics data hire and own how we go from raw WGS output to interpreted, trustworthy insights. This is a build-from-scratch role: the pipelines, the variant interpretation logic, the evidence standards, and the models we train on our data will largely be your call.
What you'll do
- Design and own our secondary/tertiary analysis pipeline: alignment, variant calling, QC, annotation
- Build the variant interpretation layer — curating evidence from ClinVar, gnomAD, GWAS Catalog, PharmGKB and similar sources into wellness and trait insights
- Develop and validate polygenic risk scores and trait-prediction models
- Evaluate and deploy modern variant effect predictors
- Work with our product/engineering lead to ship insights into the customer-facing product
What we're looking for
- PhD or MS in computational biology, bioinformatics, human genetics, or a closely related field
- Hands-on experience with human genetic data (VCF wrangling, Python interpretation libraries) and inference with SOTA in-silico variant effect prediction models (AlphaGenome, Enformer, SpliceAI, etc.)
- Strong Python and SQL;
- Working knowledge of statistical genetics — PRS construction, GWAS interpretation, population stratification
- Ability to read a paper, judge the evidence, and decide whether it belongs in a consumer product
- Bias toward shipping. You've worked somewhere small or you want to.
Why join
- Founders' previous companies have driven over $30M in revenue and 5B views on social media
- This is not a traditional, slow-moving life-sciences company, we will taking frontier research and quickly delivering it to the masses
Compensation
- $100K - $130K competitive equity
Salary : $100,000 - $130,000