What are the responsibilities and job description for the Research Associate I/II, Preclinical Research (Contract) position at Lexeo Therapeutics?
Role Summary
The Research Associate I/II will support Lexeo’s human induced pluripotent stem cell–derived cardiomyocyte (iPSC-CM) platform, a core in vitro system used to evaluate target engagement, mechanism of action, and potency across discovery and preclinical programs. This hands-on laboratory role will execute established cellular and molecular assays, contribute to assay development, and generate high-quality data. The position reports to the Head of Cardiac Research and receives day-to-day scientific direction from the Preclinical Scientist leading the platform. This is an exciting opportunity to join a cutting-edge drug discovery team advancing new therapies for patients with genetic heart disease while gaining valuable experiences for a future career in biotech and medicine
\n- Generate and validate cellular knockdown and overexpression models
- Culture and maintain human iPSC-derived cardiomyocytes and other mammalian cell lines using aseptic technique
- Perform ddPCR, qPCR, conventional PCR, gel electrophoresis, Western blotting, and ELISA to support mechanism-of-action and target-validation studies
- Maintain complete and accurate laboratory records and contribute to the development and revision of assay SOPs
- Analyze experimental data and prepare concise summaries for Preclinical team
- Bachelor’s degree in cell biology, molecular biology, pharmacology, or a related field with 1-3 years of industry and/or academic lab experience
- Hands-on experience culturing iPSC and differentiation protocols for cardiomyocytes/neurons
- Hands-on experience with cellular transfection methods
- Experience with several of the following methods: ddPCR, qPCR, semi-quantitative PCR, Western blotting, ELISA, flow cytometry, and fluorescence microscopy
- Strong laboratory skills, rigorous record-keeping, attention to detail, and the ability to work effectively in a fast-paced environment
- Ability to work onsite 5 days/week at our New York City HQ
- Prior experience in an in vitro pharmacology group within the biotechnology or pharmaceutical industry
- Experience with high-throughput screening platforms, automation and workflows
- Experience with the Jess automated Western blotting platform
- Experience with TR-FRET, NanoBiT, FLIPR, or MEA assays
- Familiarity with engineered heart tissue models and cardiac biology
- Familiarity with AI-native, agentic lab-in-the-loop workflows connecting experimental design, automated execution, real-time data analysis, and iterative decision-making
- Demonstrated ability to generate, document, and communicate high-quality experimental results; publications or patents are a plus
About LEXEO
Lexeo Therapeutics is a New York City-based, clinical stage company dedicated to reshaping the path of genetic disease. By advancing pioneering science, Lexeo seeks to set a new standard in the treatment of cardiovascular and neurological genetic diseases, charting the path to patient outcomes once thought out of reach. The Company is advancing a portfolio of therapeutic candidates designed to address the underlying genetic causes of disease, including LX2006 for Friedreich ataxia (FA), LX2020 for plakophilin-2 (PKP2) arrhythmogenic cardiomyopathy, and others in devastating diseases with high unmet need.
LEXEO Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.