Computational Biologist

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Job Title: Computational Biology Scientist, Antibody Engineering

Location: Rockville, MD (100% Onsite)

Hours/Schedule: Monday–Friday, 9:00 AM – 5:00 PM

Compensation: $45.00 – $70.00/hour

Type: Contract (6 months, extension possible but not guaranteed)

Overview

Leading biotechnology organization focused on cancer therapeutics is seeking a Computational Biology Scientist, Antibody Engineering to support next-generation antibody discovery. This is a highly impactful, first-of-its-kind role within the organization, working at the intersection of structural biology, computational modeling, and AI-enabled protein engineering.

Responsibilities

• Develop and apply computational methods to engineer monoclonal and bispecific antibodies (90% computational/10% bench work)
• Integrate deep-learning and physics-based models for protein structure prediction and developability assessment
• Analyze structural biology and NGS datasets to guide antibody library design and optimization
• Build and maintain Python-based bioinformatics and machine learning workflows for data processing and modeling
• Collaborate closely with experimental scientists to translate computational insights into actionable design decisions
• Perform limited bench-based molecular biology work, including cloning and experimental support (up to 10%)
  
  

Requirements

• Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Sciences, Computational Biology, Bioengineering, Machine Learning, Computer Science, or related field with 0–3 years postdoctoral experience OR; Master’s degree with 5 years of relevant industry experience
• Strong background in structural biology, including peer-reviewed publications
• Hands-on experience with protein modeling and structure prediction tools such as AlphaFold, RosettaFold, Schrödinger, MOE, or RFdiffusion
• Advanced Python programming skills for data analysis, automation, and ML workflow integration
• Experience with NGS data analysis and bioinformatics pipelines
• Familiarity with AI/ML approaches in protein engineering preferred but not required if structural biology and Python expertise are strong
• Ability to work effectively in highly collaborative, interdisciplinary research teams
• Must be legally authorized to work in the United States for any employer
  
  

Benefits

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.

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Ref: #558-Scientific

System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

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