Senior Research Associate

Berkeley Lab's (LBNL) Joint Genome Institute (JGI) is looking for a Senior Research Associate to join the Genome Technologies Group.

In this role, you will perform production and research assignments, preliminary data analysis and interpretation related to various technology in Next Generation Sequencing (NGS) library construction and tasks necessary to meet the goals of the large-scale genome, transcriptome, and epigenome characterization effort. Tasks involve sample management, evaluation of sample quality, library construction, library quality evaluation and submission using LIMS systems. You will be responsible for understanding the latest sequencing technology, supporting new technology development, and integrating new protocols onto the JGI sequencing platforms. Additionally, you will interpret rolling quality control (rQC) reports, troubleshoot process failures, and participate in optimization of protocols. Emphasis will be placed on meeting the library production goals as well as conducting research and development (R&D) experiments.

The JGI's mission is to provide the global research community with access to the most advanced integrative genome science capabilities in support of the DOE"s research mission to solve the world's evolving energy and environmental challenges. The JGI supports projects in genome sequencing, synthesis, transcriptomics, metabolomics, and natural products in plants, fungi, algae, and microorganisms. This position is headquartered on the Lab's main site at the Integrative Genomics Building (IGB) (Virtual Tour).

This position has an anticipated start date of May 20, 2024.

What You Will Do:

• Create various types of libraries from samples (DNA, RNA, chromatin, or cell/nuclei) from JGI users' including prokaryote, eukaryotic organisms, and environmental samples.
• Understand and interpret QC results and implement modifications.
• Follow up with accurate data entry into the LIMS system.
• Interpret rQC reports to evaluate library quality and identify failure and propose solutions.
• Design and perform experiments, summarize results, and provide conclusions on R&D projects.
• Understand general library development issues relating to production needs, identify areas of improvement, and offer feedback.
• Troubleshoot & optimize current library construction protocols to meet scientific research goals.
• Serve as a technical resource to other members in the group and recommend process and database improvements.
• Assist in project coordination with Project Management.
• Maintain an accurate and detailed laboratory notebook: document any deviations from established protocols.
• Write, update, and maintain Standard Operating Procedures (SOP).
• Attend and present project progress in group meetings.
• Participate in cross-team and cross-group training to develop knowledge of the entire workflow.
• Contribute to data, text in group publications.
• Assist group members in performing new molecular biology experiments and protocols.
• Research articles and literature to explore new techniques or applications.

What is Required:

• A Bachelor's Degree (or equivalent knowledge/training) in Biology, Molecular Biology, Microbiology, Genetics, or a related field and a minimum of 2 years of experience with molecular biology techniques including nucleic acid purification, DNA cloning, PCR, NGS library preparation and sequencing or an equivalent combination of education and experience.
• Strong analytical skills including the ability to problem solve, troubleshoot experimental processes, and provide analysis.
• Strong oral and written communication skills including the ability to organize and share analysis reports.
• Demonstrated interpersonal skills including the ability to work autonomously and as part of a diverse collaborative team.

Desired Qualifications:

• A Master's Degree (or equivalent knowledge/training) in Biology, Molecular Biology, Microbiology, Genetics, or a related field.
• Experience with sequence data analysis/interpretation.
• Experience with lab automation and data management.
• Experience mentoring Research Technicians and Students.
• Knowledge of gene expression, epigenetic regulations, and plant genomics.

Notes:

• For full consideration, please apply with a resume by April 30, 2024.
• This is a full-time career appointment, exempt (monthly paid) from overtime pay.
• This position is expected to pay $64,056 - $81,600 per year for job code 381.2, which fits within the full salary range of $64,056 - $99,132 per year. Salary for this position will be commensurate with the final candidate's qualifications and experience, including skills, knowledge, relevant education, certifications, plus also aligned with the internal peer group.
• This position is represented by a union for collective bargaining purposes.
• This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
• This position will be performed onsite at Lawrence Berkeley National Lab, 1 Cyclotron Road, Berkeley, CA 94720.
• This position is not eligible for visa sponsorship.

Learn About Us:

Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 16 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.

Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, a retirement program that is second to none, and outstanding development opportunities. To view information about the many rewards that are offered at Berkeley Lab- Click Here.

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Berkeley Lab is an Equal Opportunity and Affirmative Action Employer. We heartily welcome applications from women, minorities, veterans, and all who would contribute to the Lab's mission of leading scientific discovery, inclusion, and professionalism. In support of our diverse global community, all qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.

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