What are the responsibilities and job description for the Senior Scientist position at K3-Innovations, Inc.?
Scientist III – Analytical Characterization
Location: Worcester, MA | 100% Onsite
Contract: 1 Year Potential Extension
Relocation: Open to candidates willing to relocate
Interview: Virtual
Positions: 1
Position Summary
We are seeking a Scientist III to support analytical characterization of biologics and large molecules. The primary focus is hands-on mass spectrometry/LC-MS and protein characterization, rather than small-molecule analysis.
The ideal candidate can independently design and execute experiments, troubleshoot analytical challenges, interpret data, and communicate scientific findings.
Key Responsibilities
- Perform LC-MS analysis of biologics/proteins, including intact/reduced mass analysis and peptide mapping.
- Perform protein characterization, sequence verification, and PTM analysis.
- Conduct HPLC/UPLC separation and fractionation of protein variants.
- Design, execute, and troubleshoot analytical/method-development experiments.
- Generate accurate, reliable, and reproducible analytical data.
- Document experiments and results in ELN.
- Prepare technical reports and communicate findings to internal teams and clients.
- Maintain laboratory equipment and follow laboratory safety and quality procedures.
Must-Have Qualifications
- Strong hands-on Mass Spectrometry / LC-MS experience.
- Experience with biologics, proteins, or large-molecule characterization.
- Experience with intact protein analysis and/or peptide mapping.
- Understanding of protein structure and PTMs.
- Hands-on HPLC/UPLC experience.
- Ability to independently design, execute, troubleshoot, and interpret experiments.
- Strong scientific documentation and communication skills.
- BS/MS/PhD in Chemistry, Biochemistry, Biology, or related field.
Preferred
- Orbitrap experience.
- AKTA/fractionation.
- DSC/biophysical characterization.
- Capillary electrophoresis.
- MS data analysis/bioinformatics.
- IR/NIR/Raman or metabolomics experience.
- Pharmaceutical/biotechnology industry experience.
Important: Strong biologics-focused Mass Spectrometry/LC-MS experience is the key priority. AKTA, DSC, and other supporting techniques can be trained.
Experience: Relevant technical expertise is more important than a strict years-of-experience cutoff. PhD candidates may also be considered.