Senior Scientist, CMC & External Manufacturing

About Judo BioJudo Bio is a Series A funded biotechnology company pioneering the delivery of oligonucleotide medicines to the kidney to treat systemic and renal diseases. Our proprietary STRIKE platform (Selectively Targeting RNA Into Kidney) leverages the kidney-specific Megalin receptor to enable precise, cell-targeted delivery of siRNA therapeutics. This innovative approach allows us to address historically intractable diseases by initially targeting solute transporters in proximal tubule epithelial cells, offering new hope for conditions such as metabolic disorders, diabetes, and cardiovascular disease. Supported by a network of leading experts and a growing internal team, we are thoughtfully building a collaborative, science-driven organization focused on advancing transformative therapies that have potential to meaningfully improve the lives of patients and families.Position Overview:Judo Bio is seeking highly motivated Senior Scientist (title to commensurate with experience) with 4-8 years of industry experience to support oligonucleotide CMC development activities from early discovery through IND-enabling stages. Reporting to the VP/Director, CMC, this individual will contribute to drug product formulation development, analytical characterization, external partner coordination, and broader CMC activities to support advancement of oligonucleotide therapeutics. The successful candidate will also serve as a key interface between internal scientific teams and external partners, playing a critical role in advancing pipeline programs.Key Responsibilities:• Support in-house and external oligonucleotide drug product formulation development activities, including formulation preparation, process optimization, and troubleshooting to improve product quality and performance.• Prepare and evaluate formulations to support preclinical in vivo and non-human primate (NHP) studies.• Support internal analytical characterization of drug substance (DS) and drug product (DP), including interpretation of process and analytical data to aid development decisions.• Coordinate technical activities and communication with internal stakeholders and external CDMO partners to support process development, analytical development, manufacturing, and scale-up activities.• Contribute to CMC documentation and regulatory submission (e.g., IND-enabling activities) and support program execution through effective planning, organization, and cross-functional collaborationQualification:• PhD in Chemistry, Pharmaceutical Sciences, Chemical Engineering or related discipline. (MS candidates with substantial relevant industry experience will also be considered)• 4–8 years of relevant industry experience in pharmaceutical or biotechnology CMC development.• Hand-on experience with oligonucleotide and/or conjugates formulation development is required• Working knowledge of phase-appropriate CMC development and familiarity with regulatory documentation to support IND-enabling.• Experience working with CDMOs and external development/manufacturing partners is preferred.• Strong scientific judgment, problem-solving ability, and attention to detail, with the ability to work effectively in a fast-paced, collaborative environment.Why Join Us:This is a high-impact role offering significant visibility and influence across CMC strategy and execution. You will play a direct role in advancing innovative oligonucleotide therapeutics into the clinic, working within a collaborative, fast-paced environment that values scientific rigor, ownership, and execution.