What are the responsibilities and job description for the Purification Scientist position at Joulé?
Job Title: Purification Scientist
Location: Boston, MA
Work schedule: Mon - Fri, 8am - 5pm
Pay Range: $40.00 - $46.55/hr
Type: Contract, Potential for extension or conversion to permanent
Overview
We are seeking a highly motivated Contractor – Purification Scientist to join our Downstream Process Development team. The successful candidate will contribute to the purification and characterization of viral vectors, biologics, or recombinant proteins to support process development and manufacturing activities. The ideal candidate has hands-on experience in ion-exchange chromatography, affinity purification, and tangential flow filtration (TFF), with a strong understanding of purification principles and data analysis.
Requirements
Education:
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
Ref: #558-Scientific
Location: Boston, MA
Work schedule: Mon - Fri, 8am - 5pm
Pay Range: $40.00 - $46.55/hr
Type: Contract, Potential for extension or conversion to permanent
Overview
We are seeking a highly motivated Contractor – Purification Scientist to join our Downstream Process Development team. The successful candidate will contribute to the purification and characterization of viral vectors, biologics, or recombinant proteins to support process development and manufacturing activities. The ideal candidate has hands-on experience in ion-exchange chromatography, affinity purification, and tangential flow filtration (TFF), with a strong understanding of purification principles and data analysis.
Requirements
Education:
- Master’s degree in Biochemistry, Chemical Engineering, Biotechnology, or related field.
- Minimum 2 years of hands-on purification experience in an academic or industry setting.
- Strong knowledge and practical experience with ion-exchange and affinity chromatography.
- Familiarity with buffer preparation.
- Understanding of basic analytical methods for product characterization.
- Strong attention to detail and excellent documentation habits.
- Effective communication and teamwork skills.
- Ability to manage multiple tasks and meet project timelines.
- Experience in AAV or other viral vector purification.
- Experience with AKTA systems and Unicorn software.
- Execute purification processes including affinity chromatography (e.g., AVB, CaptureSelect), ion-exchange chromatography (AEX, CEX), and other polishing steps.
- Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs.
- Perform TFF operations for buffer exchange and concentration of intermediate or final products.
- Support experimental design, data collection, and documentation following established procedures and GMP/GLP best practices.
- Assist in troubleshooting and optimization of purification processes.
- Analyze in-process and purified samples using relevant analytical methods (e.g., UV, SDS-PAGE, ddPCR, ELISA, or HPLC).
- Collaborate cross-functionally with upstream, analytical, and manufacturing teams.
- Maintain lab equipment, manage buffers and column inventory, and ensure compliance with safety and documentation standards.
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
Ref: #558-Scientific
Salary : $40 - $47