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Senior Clinical Enterprise Architect - Healthcare

IS3 Solutions
Indianapolis, IN Full Time
POSTED ON 5/8/2026
AVAILABLE BEFORE 6/5/2026
Position Overview:

The Senior Enterprise Architect serves as a strategic architecture leader and deputy-level partner to executive technology leadership. This role represents and applies enterprise architecture strategy across the organization, ensuring business and clinical initiatives align with enterprise direction, principles, and long-term target state intent.

The Senior Enterprise Architect provides architectural leadership for large-scale enterprise and clinical transformations, including electronic health record platform transitions, application portfolio modernization, and capability-driven roadmaps. The role leads multiple architecture teams, including clinical solution architects, and operates with enterprise-wide influence comparable to a Chief Enterprise Architect in environments where the formal EA practice is still maturing.

Responsibilities:

  • Represent and apply enterprise architecture strategy across assigned business and clinical domains, ensuring initiatives align with enterprise direction, principles, and long-term target state intent.
  • Serve as the architectural leader for major electronic health record transformations, including Cerner to Epic transitions, ensuring clinical, operational, regulatory, and technical alignment.
  • Act as a senior deputy to executive technology leadership, providing architecture guidance, challenge, and decision support comparable to a Chief Enterprise Architect role.
  • Partner directly with executive, business, and clinical leaders to understand objectives, constraints, and priorities, translating strategy into enterprise capabilities, roadmaps, and architectural implications.
  • Identify, assess, and shape enterprise initiatives to ensure architectural coherence, appropriate sequencing, and measurable value realization.
  • Lead and mentor multiple architecture teams, including clinical solution architects and domain architects, ensuring consistent application of enterprise standards and architectural practices.
  • Ensure enterprise capabilities and roadmaps are synchronized across clinical, infrastructure, data, security, and business domains, proactively surfacing conflicts, dependencies, risks, and opportunities.
  • Collaborate with domain, solution, and clinical architects to guide architectural decisions, ensuring solutions remain fit for purpose while conforming to enterprise standards.
  • Provide architectural insight and executive-level decision support to enable informed trade-offs related to investment, risk, and execution.
  • Contribute to enterprise-level learning and continuous improvement by sharing patterns, outcomes, and lessons learned to inform the evolution of the enterprise architecture practice.

Qualifications:

  • Ten or more years of progressive experience in enterprise architecture, solution architecture, or senior technical leadership roles within complex, multi-domain environments.
  • Demonstrated experience operating at a senior or deputy enterprise architecture leadership level, with accountability similar to a Chief Enterprise Architect in practice.
  • Proven experience leading large-scale healthcare transformations, including enterprise electronic health record transitions such as Cerner to Epic.
  • Demonstrated experience leading and mentoring multiple architecture teams, including clinical solution architects, within federated or matrixed organizations.
  • Strong experience aligning enterprise, business, and clinical strategy to technology execution, including translating objectives into capabilities, roadmaps, and architectural direction.
  • Proven ability to partner with executive, business, and clinical leaders and influence decision making across organizational boundaries without direct authority.
  • Experience operating within a federated or matrixed architecture model, balancing enterprise standards with business and clinical autonomy.
  • Strong architectural judgment across application, infrastructure, integration, data, security, and cloud platforms.
  • Experience supporting large-scale initiatives involving multiple teams, vendors, and technologies with accountability for enterprise coherence and outcomes rather than delivery ownership.
  • Ability to communicate complex architectural concepts clearly to technical, business, and clinical audiences.

Tools and Technologies:

  • Enterprise architecture frameworks such as TOGAF or ISO/IEC 42010
  • Epic electronic health record platforms and surrounding clinical ecosystems
  • Cerner electronic health record platforms and enterprise transition experience
  • FHIR-based integration architectures and clinical data platforms
  • Application portfolio management and rationalization practices
  • Capability-based planning and multi-year enterprise roadmap development

Salary.com Estimation for Senior Clinical Enterprise Architect - Healthcare in Indianapolis, IN
$68,558 to $96,167
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