What are the responsibilities and job description for the Vice President, Clinical Development – Cardiovascular position at Ionis Pharmaceuticals, Inc.?
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.
At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.
With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.
We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
VICE PRESIDENT, CLINICAL DEVELOPMENT - CARDIOVASCULAR
Summary
The Vice President, Clinical Development – Cardiovascular is responsible for defining and driving the clinical development strategy for Ionis’ cardiovascular portfolio and for contributing to enterprise-level development and portfolio decisions.
This role operates with a high degree of independence and accountability, directly influencing corporate strategy, portfolio prioritization, and investment decisions. The VP partners closely with senior leadership across Development, Research, Regulatory Affairs, and Commercial to ensure that clinical programs are scientifically rigorous, operationally executable, and positioned to deliver meaningful value to patients and the company.
The VP is accountable for advancing multiple clinical programs across stages of development, including phase 4 and post marketing studies, and for making complex, high-impact decisions in areas where data may be limited and risk is significant.
This role will report to the Senior Vice President, Global Cardiovascular Development and will manage direct reports.
Responsibilities
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
Full Benefits Link: https://ionis.com/careers#:~:text=Highly competitive benefits
The pay scale for this position is $338,814 to $423,694
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.
With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.
We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!
VICE PRESIDENT, CLINICAL DEVELOPMENT - CARDIOVASCULAR
Summary
The Vice President, Clinical Development – Cardiovascular is responsible for defining and driving the clinical development strategy for Ionis’ cardiovascular portfolio and for contributing to enterprise-level development and portfolio decisions.
This role operates with a high degree of independence and accountability, directly influencing corporate strategy, portfolio prioritization, and investment decisions. The VP partners closely with senior leadership across Development, Research, Regulatory Affairs, and Commercial to ensure that clinical programs are scientifically rigorous, operationally executable, and positioned to deliver meaningful value to patients and the company.
The VP is accountable for advancing multiple clinical programs across stages of development, including phase 4 and post marketing studies, and for making complex, high-impact decisions in areas where data may be limited and risk is significant.
This role will report to the Senior Vice President, Global Cardiovascular Development and will manage direct reports.
Responsibilities
- Maintain deep expertise in cardiovascular and cardiometabolic disease, including lipid disorders such as hypercholesterolemia, hypertriglyceridemia, and lipoprotein(a)–mediated risk.
- Apply current and emerging science in lipid biology and cardiovascular risk reduction to inform clinical development strategies and portfolio decisions.
- Guide development of clinical programs targeting lipid-modifying therapies, including selection of appropriate patient populations, biomarkers, and endpoints.
- Provide leadership on the design and interpretation of cardiovascular outcomes trials (CVOTs) and other studies evaluating impact on major adverse cardiovascular events (MACE).
- Integrate translational insights (e.g., mechanism of action, biomarker response, genetic validation) into clinical development plans to strengthen probability of success.
- Guide interpretation of complex clinical and biomarker data, including lipid parameters and cardiovascular risk markers, and translate findings into strategic program decisions.
- M.D. with significant experience in clinical development within the biopharmaceutical industry.
- Deep expertise in cardiovascular disease, with strong experience in lipid disorders and cardiometabolic disease (e.g., dyslipidemia, atherosclerosis, triglyceride metabolism, Lp(a)).
- Demonstrated success leading development of therapies targeting cardiovascular risk factors, including experience with lipid-modifying agents and/or outcomes-based clinical programs.
- Experience designing and interpreting studies involving lipid biomarkers, surrogate endpoints, and cardiovascular outcomes (e.g., MACE).
- Proven ability to translate mechanistic and translational science (including genetics and biomarker data) into clinical development strategy.
- Demonstrated success leading clinical development programs across multiple stages, including late-stage development.
- Proven ability to make high-quality decisions in complex, ambiguous situations with meaningful business impact.
- Experience influencing portfolio strategy and contributing to investment or prioritization decisions.
- Strong leadership and influencing skills, with the ability to drive outcomes across cross-functional teams.
- Experience interacting with regulatory agencies and external experts.
Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits
Full Benefits Link: https://ionis.com/careers#:~:text=Highly competitive benefits
The pay scale for this position is $338,814 to $423,694
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.
Salary : $338,814 - $423,694