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Associate Director of Pathology

Ionis Pharmaceuticals, Inc.
Carlsbad, CA Full Time
POSTED ON 4/9/2026
AVAILABLE BEFORE 6/11/2026
Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

ASSOCIATE DIRECTOR OF PATHOLOGY

Responsibilities

Ionis is seeking a talented and highly motivated Pathologist within the Preclinical Development Department to provide strategic scientific leadership in the assessment of nonclinical safety of candidate medicines. The Preclinical Development Department includes highly collaborative scientists who provide a supportive environment that fosters growth and learning. Key responsibilities include:

  • Conduct histopathology review of internal and outsourced non-GLP and GLP research, pharmacology, and toxicology studies and provide interpretation that integrates all study data
  • Serve as nonclinical safety representative on cross-functional project teams based on interest
  • Contribute to the design of non-GLP and GLP nonclinical studies
  • Provide strategic input on the nonclinical toxicology and regulatory approach for IND-enabling packages and for clinical stage programs
  • Author nonclinical sections of regulatory documents (e.g. IB, IND, NDA, DSUR, etc) and represent Ionis in meetings with regulatory authorities
  • Assess mechanism(s) of toxicity to determine clinical relevance and impact
  • Communicate pathology and nonclinical safety findings, interpretation, and impact to teams and governance committees
  • Represent Ionis externally (e.g. at scientific meetings and/or through participation in industry consortia, working groups, and/or professional societies)
  • Publish findings in high impact peer-reviewed journal

Requirements

  • DVM (or equivalent)
  • PhD in pathology, toxicology, or related life sciences discipline
  • Board-certification in anatomic pathology (e.g. ACVP, ECVP)
  • At least 5 years of experience in toxicologic pathology of multiple species in the pharmaceutical or biotechnology field with a focus on IND-enabling packages and beyond
  • Experience with digital pathology and image analysis is a plus
  • Experience with regulatory submissions and interactions
  • Demonstrated strong decision-making and problem-solving skills
  • Team player with proven interpersonal and communication skills
  • Dedication to life-long learning and professional development

Please visit our website, www.ionis.com for more information about Ionis and to apply for this position; reference requisition #IONIS003712

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://www.ionis.com/careers/working-at-ionis/#:~:text=to Applicants »-,Benefits,-Employees are rewarded

The pay scale for this position is $169K,000 to $237,000

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Salary : $169,000 - $237,000

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