Scientist

Title: NGS Scientist

Location: Boston, MA

contract: 6-Month Contract

We are seeking an experienced NGS Scientist to join a leading Cardiometabolic Research team focused on advancing therapies for diabetes, obesity, cardiovascular disease, and metabolic disorders. This role will support cutting-edge sequencing workflows and collaborate across multiple therapeutic areas within a fast-paced research environment.

Key Responsibilities

• Perform NGS library preparation workflows including bulk RNA-seq, scRNA-seq, and snRNA-seq
• Execute sequencing, quantification, QC analysis, and sample preparation activities
• Develop and optimize new NGS workflows to support evolving research needs
• Maintain SOPs and ensure consistent delivery of high-quality sequencing data
• Collaborate cross-functionally while managing multiple sequencing requests and timelines
• Handle inventory management for RNA/DNA samples, libraries, and sequencing reagents
• Support additional molecular biology tasks including RNA extraction, qPCR, and ddPCR
• Maintain accurate experimental documentation using electronic lab notebooks (ELN)
• Assist in evaluating sequencing workflows across partner sites and CROs

Required Qualifications

• B.S. or M.S. in Biology, Molecular Biology, Biochemistry, or related scientific field
• 3–5 years of hands-on laboratory research experience
• Strong background in NGS technologies and their applications, including quantification, sequencing, and data QC (preferably Illumina). Direct experience with RNA-seq (bulk) and amplicon-seq.
• Direct experience with single-cell and single-nucleus RNA-seq library preparation is required. Candidates must be familiar with multiple scRNA-seq/snRNA-seq platforms (e.g., 10X Genomics Chromium, Illumina PIP-seq, ScaleBio, or Parse Biosciences).

Additional Skills/Preferences:

• Familiarity with CRISPR-based gene editing and high-throughput screening is a plus.
• Experience with automation is a plus (Mantis, Integra systems, Liquid Handlers, SPTLabtech Firefly, Tecan, etc).
• Strong organizational, time management, and communication skills.
• Experience with documentation in electronic notebook software.