What are the responsibilities and job description for the Antibody and Protein Engineering Platform Head position at Innovent Biologics?
Job Responsibilities
- Proficient in the full process of antibody discovery, guiding antibody screening platforms (e.g., hybridoma, single B-cell, display platforms) for antibody selection.
- Responsible for antibody and protein engineering modifications, including humanization, affinity maturation, de-immunization, stability optimization, Fc engineering, and cytokine modifications.
- Lead the design and molecular optimization of bispecific and multispecific antibody formats, ensuring expression levels, developability, immunogenicity, and pharmacokinetic properties meet downstream development requirements.
- Conduct high-throughput expression of antibodies and proteins, along with early-stage developability testing and physicochemical characterization.
- Collaborate closely with cross-functional teams (e.g., functional biology, pharmacology) to advance project progress.
- Provide strategic recommendations at internal project reviews and leadership meetings.
- Track cutting-edge technologies (e.g., AI-assisted antibody discovery, novel antibody development) to continuously optimize and upgrade the R&D platform.
Job Qualifications
- Education and Major: Ph.D. in Molecular Biology, Structural Biology, Genetic Engineering, Bioengineering, Biopharmaceuticals, or related fields.
- Professional Knowledge: Expertise in antibody development techniques, including hybridoma, phage/yeast display, molecular cloning, protein expression and purification, and affinity maturation, with a focus on antibody engineering.
- Work Experience:
- Minimum 10 years of industrial R&D experience in antibody discovery or protein engineering, with a preference for candidates who have successfully led projects to PCC and clinical stages.
- Overseas background, especially experience in multinational pharmaceutical companies, is preferred.
- Experience in managing teams of 30 members, with strong adaptability and problem-solving skills in high-pressure, fast-changing environments.
- Proficiency in antibody and protein structural analysis, with hands-on experience in designing and optimizing bispecific and multispecific antibodies.
- Deep understanding of antibody structure-function relationships, sequence optimization, and expression/purification workflows.
- Familiarity with antibody developability and immunogenicity assessment, Fc engineering, and half-life extension strategies.
4.Skills:
- Excellent research capabilities, demonstrated by patents or scientific achievements.
- Proficiency in English as a working language.
5.Other Requirements:
- Strong team management and leadership abilities.
- Ability to adapt quickly and handle complex tasks under pressure and rapid changes.