Postdoctoral Fellow in Stem Biology (Otolaryngology Dept)

A post-doctoral fellow position is available immediately to join the Hashino Stem Cell Research Lab at Indiana University School of Medicine, and study normal and pathological development of the human inner ear using stem cell-derived organoids as a model system (Koehler et al., Nature Biotechnology 2017; Nie et al., Nature Communications 2022; Moore et al., Cell Stem Cell 2023). We recently developed a human cochlear organoid system that recapitulates many aspects of hair cell and spiral ganglion neuron development. Using this novel model system, we aim to elucidate the mechanisms underlying hair cell differentiation and identify means to promote hair cell regeneration in the human cochlea. We are also developing a human cochlea–hindbrain assembloid system to study auditory neural circuity development. Applicants should have a Ph.D. degree or equivalent in biomedical sciences. The starting date is flexible.

The Hashino lab is a highly collaborative group of scientists with diverse research backgrounds ranging from chemical engineering to stem cell biology, neuroscience and molecular biology. We conduct team-based science, while fostering independence and creative approaches to addressing fundamental scientific questions.

The experimental approaches we are currently using include: human pluripotent stem cell-derived organoid culture, CRISPR genome editing, CUT&RUN/ChIP, scRNA-seq/scATAC-seq, super-resolution/expansion microscopy, calcium imaging, proteomics, hydrogel fabrication/characterization, bioprinting and computational modeling.

IU School of Medicine is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.