Principal Investigator, Clinical Pharmacology & Pharmacometrics

Overview

A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity

Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.

Job Summary: (Primary function)

This position will be responsible for performing pharmacometric modeling and simulations including but not limited to population PK/PD, (semi-)mechanistic PK/PD, PBPK, and QSP, etc., to support early clinical development for biologics and small molecules. Levels will be commensurate with qualifications and experience.

Essential Functions Of The Job (Key Responsibilities)

• Develop and execute pharmacometric modeling and simulations strategy in support of clinical development programs, regulatory/submission strategy and related documents
• Perform PK/PD analyses and/or population PK/PD analyses, interpret and report data to clinical teams and management in a timely manner.
• Perform (semi-)mechanistic PK/PD, PBPK, and/or QSP modeling and simulations that yield high value PK/PD information for critical clinical development decisions.
• Work with other functions such as clinical development, biostatistics, data management, medical writing, and regulatory affairs, etc., to provide deliverables on time.
• Present work internally and at external scientific meetings and publish manuscripts in peer-reviewed journals.
  
  

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Ph.D. in Pharmacokinetics, Pharmacometrics, Pharmacology, Pharmaceutical Science, Chemical/Biomedical engineering, Statistics or related fields.
• 1-5 years post-PhD or 3-7 years post-MSc of experience in population PK/PD analysis, PBPK, and/or QSP modeling and simulations.
• Levels will be commensurate with qualifications and experience.
• Experience in multiple software packages such as R, NONMEM, Monolix, MatLab, Simcyp, GastroPlus, or other pharmacokinetic, modeling and data visualizations software.
• Scientific understanding of biopharmaceutical and ADME properties of both small molecules and biologics
• Experience in scheduling and execution of multiple programs and projects, in a dynamic and cutting-edge research environment;
• Excellent communication skills (verbal and written) and presentation skills
• Ability to work independently
  
  

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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