Research Associate III, Bioconjugation Chemistry

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets.

Position Overview

As a Research Associate III at Immunome, Inc., you will be a key contributor to our research and development initiatives, driving the optimization and delivery of antibody-drug conjugates (ADCs). In this role, you will design, produce, and characterize ADCs in support of program-specific objectives, while collaborating closely with cross-functional partners. Your expertise in bioconjugation will provide critical insights that help advance our therapeutic pipeline and strengthen our scientific capabilities.

Responsibilities

Research Design and Execution

• Generate high quality ADCs to enable advancement of named programs.
• Evaluate innovative bioconjugation and linker technologies.
• Assess developability of discovery stage ADCs.
• Work collaboratively with cross-functional teams to plan experiments aimed at advancing drug development projects.
• Independently perform laboratory experiments in accordance with established protocols, maintaining the highest standards of scientific rigor, documentation, and data integrity.
• Continuously optimize laboratory processes to improve workflow efficiency, reproducibility, and throughput.
• Manage ADC inventory and coordinate delivery of samples to cross-functional partners.
• Data Analysis and Interpretation:
• Characterize biophysical properties of ADCs using various techniques, such as analytical SEC, HIC, PLRP, and LC-MS.
• Interpret results and draw meaningful conclusions to guide decision-making.

 Project Collaboration

• Collaborate with colleagues from diverse scientific disciplines to achieve project goals.
• Participate in project team meetings, providing expertise and insights to drive projects forward.

Continuous Learning and Development

• Stay informed about the latest bioconjugation advancements in the ADC field.
• Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.

Qualifications

• BS or MS in Biochemistry, Chemistry, or related field.
• Minimum of 5 years of experience (or 3 years of experience for MS) in preclinical drug development in the biotechnology or pharmaceutical industry.
• Proficiency in bioconjugation techniques and demonstrated experience in ADC pre-clinical development is a requirement.

Knowledge and Skills

• Proficient in analytical techniques and purification methods relevant to biologics and ADC development (SEC, HIC, PLRP, and LC-MS, etc).
• Experience in antibody engineering and protein modification is a plus.
• Excellent communication skills, both written and verbal, to effectively collaborate with cross-functional teams and communicate scientific concepts to non-scientific stakeholders.
• Proven ability to adapt to changing priorities and work in a fast-paced, dynamic environment.
• Experience with Agilent OpenLab and Benchling is a plus.

Please note, the internal title for this role is Research Scientist II, Bioconjugation Chemistry

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

E-Verify

Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).