Principal Scientist, Protein Sciences

About iBio

iBio, Inc. is a preclinical stage biotechnology company leveraging the power of Artificial Intelligence (“AI”) for the development of hard-to-drug precision antibodies in the cardiometabolic and obesity space. Our core mission is to harness the potential of AI and machine learning (“ML”) to unveil novel biologics which other scientists have been unable to develop. Through our innovative AI Drug Discovery Platform, we have been able to identify differentiated molecules aimed to address unmet needs by current glucagon-like peptide-1 (“GLP-1”) receptor agonists. For more information, visit www.ibioinc.com or follow us on LinkedIn.

The Opportunity

Are you a visionary scientist ready to lead antibody innovation from discovery to clinic? iBio is looking for a Principal Scientist, Protein Sciences to head our protein sciences group and drive cutting-edge therapeutic antibody development, with a focus on bispecific formats.

This role is located in San Diego, CA.

In this role, you will:

• Drive the design, engineering, and optimization of therapeutic antibodies, with a strong emphasis on bispecific formats and developability considerations.
• Perform comprehensive antibody characterization using methods such as ELISA, SPR, HPLC, BLI, and related assays.
• Oversee mammalian expression systems and provide leadership in protein purification and manufacturability testing.
• Lead, mentor, train, and manage members of the Protein Sciences group, including Scientists and Research Associates.
• Collaborate closely with cross-functional teams to ensure seamless progression of programs from platform discovery through in vivo proof-of-concept studies and into development.
• Communicate research findings effectively to internal stakeholders, senior leadership, external partners, and the broader scientific community as needed.
• Contribute to regulatory documentation, support development, and ensure adherence to industry standards and best practices.
• Drive innovation and intellectual property generation, including publications and patents where appropriate.
• Stay current with scientific literature and emerging technologies to continuously strengthen the company’s protein sciences capabilities.

Experience and Skills

• Extensive hands-on experience with antibody discovery, engineering, and development, including demonstrated leadership of antibody programs in a biotech or pharmaceutical setting.
• Proven expertise with multiple bispecific antibody formats, with a strong track record of assessing and guiding developability.
• Deep technical experience in mammalian protein expression, purification, and analytical characterization using standard assays (e.g., ELISA, SPR, HPLC, BLI).
• Experience with antibody fusions, Fc-fusions, and conjugation to antibodies is highly desirable.
• Demonstrated ability to integrate deep knowledge in at least one disease area to shape and advance therapeutic programs.
• Industry experiences advancing biologic therapeutics from discovery through development, with contributions to clinical candidates.
• Successful track record of leading and mentoring scientific teams, as well as managing external collaborations with CROs or academic partners.
• Evidence of innovation and scientific leadership, including patents, publications, or conference presentations.

Education and Experience

• Bachelor’s degree in Biochemistry, Biophysics, Molecular Biology, or related field and 10 years of experience within the biotech/pharmaceutical industry; or,
• Master’s degree in Biochemistry, Biophysics, Molecular Biology, or related field and 8 years of experience within the biotech/pharmaceutical industry; or,
• PhD degree in Biochemistry, Biophysics, Molecular Biology, or related field and 5 years of experience within the biotech/pharmaceutical industry.

Characteristics of Successful Applicant

• Critical Thinking and Scientific Expertise: Strong critical thinking skills with proven expertise in antibody development, safety, and pharmacokinetics.
• Cross-Functional Collaboration: Demonstrated success in working effectively with cross-functional project teams in fast-paced environments.
• Communication Skills: Exceptional oral presentation and written communication skills.
• Analytical and Problem-Solving Abilities: Strong analytical mindset with keen attention to detail and effective problem-solving skills.
• Organizational and Time Management: Excellent organizational and time-management skills.

At iBio, your expertise will shape the future of biologics, with opportunities to drive innovation, collaborate with top scientists, and make a real-world impact.

Bring your expertise. Lead with vision. Drive discoveries that change lives.

California Base Salary Range

The expected annual base salary for this position ranges from $133,300.00 to $147,250.00, plus bonus, equity, and comprehensive benefits. The base salary range reflects the target range for this position, but individual pay will be determined by various factors, including the qualifications of the individual applicant for the position, years of relevant experience, job-related skills, relevant education attained, work location, and organizational needs. This range may be modified in the future. A discretionary annual bonus may be available based on individual and Company performance.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identify, national origin, disability, veteran status or other protected classes.

What do we offer?

We provide competitive and comprehensive benefits to our employees. Below are some highlights of our benefits:

• Medical, Dental, and Vision Insurance Options
• Flexible Time Off
• Our company observes seven designated holidays each calendar year.
• 401(k) with Company Match as described in plan documents.
• Life and Disability Insurance
• Short-term and long-term disability insurance

EEO Statement

iBio is proud of its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability, or any other legally protected status.

iBio is committed to helping individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at iBio, please email ibio_peopleculture@ibioinc.com for further assistance. Please note that this email address is intended only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Notice to Recruiters

Thank you for your interest in iBio and our recruitment opportunities. Recruiting and employment are managed through the Human Resources Department. iBio requires a signed agreement be in place prior the presentation of any candidates.We ask that recruiters and agencies do not contact or solicit employees or managers in an attempt to present candidates. iBio will not be obligated or responsible for any requested fees to candidate resumes that are unsolicited and or submitted to hiring managers without a written agreement between iBio and any recruiters and agencies.