Director, Medicinal Chemistry

At HotSpot, we’re not just looking for the brightest minds or for the most brilliant individual contributors. We want passionate team members who are comfortable adjusting their lens, aren’t afraid to think big, test bold ideas, and celebrate collective wins. We have established core values that resemble who we are and define our company culture. We are building a company where values drive everything we do inside and outside the organization.

#Courageous Adventurers #Leave your Mark #Keep it Human #Make it Real

SUMMARY:

Reporting to the Senior Director, Medicinal Chemistry, the Director role is a key leadership position within HotSpot’s drug discovery programs. The successful candidate will co-lead a discovery program team in close partnership with a lead biologist, driving strategic and scientific direction. This hybrid role, based in Boston’s Seaport District, offers a high degree of flexibility. Responsibilities include, but are not limited to, the following:

RESPONSIBILITIES: 

• Lead medicinal chemistry efforts in collaboration with biology and cross-functional partners to advance

programs from hit identification through clinical candidate nomination.

• Design new compounds for synthesis.

• Experience in leverage advanced modeling techniques and utilizing computational tools for structure

based drug design and lead optimization.

• Manage external chemistry resources (CROs), including oversight of synthesis activities, timelines, and

scientific direction to ensure quality and timely delivery.

• Work with a matrixed team in computational chemistry/ADME/pharmacology/process chemistry to

deliver high-quality output.

• Present key data, conclusions, and recommendations to project teams and senior management

effectively and concisely; support preparation of board and business development materials.

 QUALIFICATIONS: 

• Ph.D. degree in organic chemistry or medicinal chemistry and a minimum of 10 years of relevant

experience in small molecule drug discovery within pharmaceutical and/or biotech setting.

• Previous experience in chemical methodology and/or total synthesis.

• Driven, self-motivated, and proactive; able to independently identify objectives, design strategies, and

execute plans to achieve goals.

• Effective mentor and communicator; able to lead scientific discussions and influence project direction

within a collaborative, matrixed environment.

• Comfortable working within distributed team model including use of Zoom or other video-conference

tools.

• Ability to integrate data/input from different sources and team members.

• Deep expertise in synthetic chemistry and structure-based drug design.

• Experience leading medicinal chemistry efforts within cross-functional discovery teams.

• Strong track record of peer-reviewed publications and/or patent filings.

OUR BENEFITS:

We believe that people are our greatest resource and foster a supportive environment that provides growth and development for all. We recognize and reward performance and incentivize long-term success. From benefits that focus on your health and well-being to competitive compensation to equity ownership, we want to inspire our employees to be their best!

Our Benefits Include, But Are Not Limited To:

Competitive salary and discretionary bonus plans

New hire stock option award

Medical, Dental, Vision plans and fringe benefits

Generous paid holidays, time off, including 2 company-wide shutdowns

Hybrid, flexible work model: approx. 2 days/per week on site

Amazing team of supportive colleagues

At HotSpot, we have a bold mission to establish a new drug discovery paradigm. If this appeals to you, please let us know at iamcurious@hotspotthera.com.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

At this time, HotSpot is not able to offer Visa sponsorship for this position. Candidates must be authorized to work in the United States without current or future sponsorship.