Clinical Genomics Scientist I

Who We Are & What We Do

At Helix, our mission is simple: to help everyone improve their lives through their DNA.

Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.

What is special about this role?

The Department of Clinical Genomics is new to Helix, it is like a start-up within a start-up with ample opportunity for growth. You will be working on a variety of tasks, have the opportunity to bring your ideas to the table, and contribute to the overall success of our team and the company. In the Clinical Genomics team, you will enjoy a strong sense of community and will have the support you need to ensure you can deliver on the expectations of your role.

Location: Hungary - Remote (The work hours for this role will be 6:00 AM - 3:00 PM)

As a Clinical Genomics Scientist I, you will:

• Be responsible for variant and gene assessments including researching the significance of variants in published literature and clinical data, evaluating evidence for gene-disease associations, and performing data review.
• Perform technical review of sequencing data derived from NGS, including genome, exome, panel, and single-site variant data, as well as other molecular assay data.
• Compile interpretive variant summaries and contribute to clinical report writing.
• Communicate clearly with internal and external stakeholders, such as genetic counselors, physicians, lab staff, and product developers.
• Maintain laboratory variant knowledge base and assist with curation and harmonization of variant classification changes over time.
• Perform variant quality controls and maintain quality management programs according to written policies and procedures.
• Actively participate in complex variant discussions/presentations, and conferences, as needed.
• Contribute to research projects as necessary.

About you:

• PhD degree or MSc degree with expertise in molecular genetics, human genetics, molecular pathology, or related fields with 2 years of variant interpretation experience.
• Familiarity with human mutation databases, genome browsers, HGVS nomenclature, and in-silico variant pathogenicity predictors
• Familiarity with sequencing technologies
• Germline variant interpretation experience, familiarity with ACMG-AMP variant interpretation guidelines.
• Able to perform technical writing, as well as strong communication and computer skills [Google Suite, database management, etc]
• Excellent analytical skills and attention to detail
• Able to critically read and distill data from the scientific literature
• Must be able to adjust to shifting priorities according to workload or business needs
• Proficiency in reading, writing and speaking in English
• Able to work from home and engage in regular virtual meetings and collaboration with the US and Hungarian teams, including adjusting to time differences as needed. Must be available to work and attend meetings outside of regular Indian business hours.
• Ability to work on the weekends.

Pluses:

• Experience with gene-disease validity curations based on ClinGen protocols.
• Laboratory experience to be able to easily understand the scientific literature in genetics and molecular biology
• Genetic data analysis experience
• Familiarity with Integrative Genomics Viewer

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. For more information or to make an accommodation request reach out to .

Expected Interview Process:

1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer

Expected Pay For This Role:

Expected Annual Base Pay: 10,000, ,400,000 HUF

The salary range above is our reasonable estimate of the base compensation for this role across US locations. Actual starting pay will be based on non-discriminatory job-related factors, including exact work location, experience, relevant training and education, and skill level. Your recruiter can share more about your specific work location salary range during the hiring process.

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits through our EOR.

What To Expect During Your Onboarding Week:

We want to make sure your first week is spent learning the foundations. You will be invited to live orientation sessions and spend time with your hiring manager developing your individual roadmap to success. This experience will include sessions that cover your benefits, security & privacy training, an introduction to the OKR framework used at Helix and our communication tools and norms.

What To Expect During Your First 90 days:

• First 30 days: you'll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You'll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
• Day : you'll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix's products, services and capabilities.
• Day : you'll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.

Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.

LI-Remote

Salary : $100,000 - $4,000,000