Demo

Staff Program Manager, Business Operations

Guardant Health
Palo Alto, CA Full Time
POSTED ON 11/27/2025
AVAILABLE BEFORE 1/26/2026

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn , X (Twitter) and Facebook .

  • Drive effective organizational and operational planning and execution for the Biopharma business, including annual planning cycles, budget tracking, and performance reporting.
  • Partner closely with the SVP and leadership team to coordinate business priorities, manage deliverables, and ensure timely follow-up on key actions and initiatives.
  • Lead the development and management of the Biopharma operating budget, including vendor engagement, purchase order submission, invoice tracking, and collaboration with Finance and Procurement.
  • Oversee vendor management processes for general Biopharma operations, including RFPs, SOW tracking, performance reviews, and contract renewals in collaboration with Legal and Finance teams.
  • Plan and execute major departmental meetings and events, including quarterly business reviews, leadership offsites, and all-hands meetings.
  • Expected to liaise with several teams within Commercial BioPharma team, like: Commercial BioPharma Operations, BioPharma Translational teams.
  • Streamline onboarding for new team members, ensuring consistent processes, materials, and introductions across the Biopharma organization.
  • Implement and refine business processes and tools to improve team efficiency, transparency, and communication across multiple functions and geographies.
  • Serve as a key liaison between Biopharma and cross-functional partners in Finance, Legal, HR, IT, and Corporate Communications.
  • Develop and maintain internal documentation, project trackers, and other organizational tools to support alignment and accountability.
  • Support the preparation of executive materials and presentations for internal and external audiences.
  • May handle expense reporting, light travel and calendaring for SVP.
  • Monitor and report key operational metrics, proactively identifying areas for process improvement and optimization.

Qualifications and Experience

  • Bachelor’s degree required; advanced degree preferred.
  • Typically requires 8 years of related experience, including program management or business operations type roles within a commercial or biopharma organization.
  • Demonstrated success managing complex operational programs, budgets, and cross-functional initiatives.
  • Proven experience with vendor management, including budgeting, contracts, and procurement processes.
  • Strong organizational and project management skills, with ability to manage multiple priorities and stakeholders simultaneously.
  • Excellent interpersonal, written, and verbal communication skills; able to build strong working relationships across levels and functions.
  • High degree of professionalism, discretion, and judgment in handling sensitive and confidential information.
  • Advanced proficiency with productivity and collaboration tools (e.g., MS Office, Smartsheet, and similar applications).
  • Demonstrated ability to lead through influence and drive alignment across matrixed teams.
  • Travel may be up to 10–15%.


Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate’s compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need. Primary Location: Palo Alto, CA Primary Location Base Pay Range: $140,900 - $193,800 Other US Location(s) Base Pay Range: $119,800 - $164,750 If the role is performed in Colorado, the pay range for this job is: $126,800 - $174,450


Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com

A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants .

Please visit our career page at: http://www.guardanthealth.com/jobs/

Salary : $119,800 - $164,750

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