Senior Bioinformatics Systems Software Engineer

Company Description

Company Description

Guardant Health is a pioneer in non-invasive cancer diagnostics and the first company to commercialize a comprehensive genomic liquid biopsy. Our proprietary digital sequencing technology is transforming cancer treatment by providing an accurate and precise picture of the individual genomic alterations that cause tumors to grow, change, and develop resistance to treatment. We have combined decades of scientific research, advances in laboratory technology, and our breakthrough innovation in liquid biopsy to create new tests that have already handled tens of thousands of samples. We believe our tests can accelerate new drug development and improve the lives of all patients fighting cancer. Our current products are just the beginning of what we hope to accomplish, and new uses of our platform are emerging.

We succeed best by coordinating our creative talents and energies, working as a team to achieve results far beyond what any single individual could accomplish. We seek very talented people who want to be part of our fantastic team.

Job Description

You will be part of the LUNAR bioinformatics team working on and with the software that is used in the clinical laboratory to process patient samples and analyze their genomic profiles, helping to prevent recurrence of cancer for cancer survivors based on a simple blood draw. Your role will be to work with Bioinformatics SQA engineers and members of the bioinformatics group to ensure the quality of bioinformatics software used in CLIA, CAP, NYDOH, and FDA regulated environments and the correct installation on production systems.

Essential Duties and Responsibilities:

• Work with bioinformatics SQA engineers and members of the bioinformatics group to develop test cases that ensure the quality of bioinformatics software used in CLIA, CAP, NYDOH, and FDA regulated environments.
• Participate in requirements and design review meetings to create comprehensive, automated test strategies/plans for bioinformatics software leading to successful implementation and timely project completion.
• Work with the algorithm development team to understand functional specifications, identify and design test cases for sequence analysis software including alignment, variant calling, and annotation software.
• Work with cross-functional teams, and support integration and regression testing of Bioinformatics software.
• Execute complex testing, perform in-depth statistical analysis, and interpret results independently.
• Design, create, enhance, and maintain bioinformatics data simulators and automated testing framework to ensure excellent testing coverage.
• Provide written documentation and specifications of software products and services.
• Provide coaching to other team members for designing test strategies and test cases with strong knowledge of molecular biology, oncology and bioinformatics.
• Report, track, and escalate anomalies discovered during testing (All testing phases) and ensure closure on issues.
• Perform Impact Analysis for incremental changes and identify the scope of regression / test cycles and execute them as needed.

Qualifications

• Minimum with a BS  Degree in Bioinformatics or related field
• 4 years of hands on experience with programming and scripting languages such as Python, R, C , shell and RDBMS (SQL or Oracle) and software dev/QA in Linux environment.
• Strong understanding of sequencing data, annotations, and standard bioinformatics tools e.g. samtools, picard, snpEff.
• 4 years of hands on experience in scripting, running, analyzing, and refining automation frameworks for comprehensive and full application testing, including API testing.
• 4 years of experience in verifying algorithms, workflow or data analysis software.
• Experience with test case management tools and best practices for scalability and maintainability.
• 2 years of experience in Continuous Integration / Delivery tools such as Jenkins and container runtime tools such as Docker
• Excellent organization and people skills with the ability to work across functions to ensure successful integration testing.
• Experience in testing bioinformatics software is preferred
• Experience working in a regulated environment (CLIA, CAP, NYDOH, and FDA) preferred

Additional Information

Covid Vaccination Policy:  Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant’s COVID-19 U.S. Vaccination Policy as a reasonable accommodation, as consistent with applicable laws.  An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this policy by obtaining, if applicable, any FDA-approved boosters.

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

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Please visit our career page at: http://www.guardanthealth.com/jobs/

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