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Senior Research Scientist, Biophysics

GQR
South San Francisco, CA Contractor
POSTED ON 7/29/2026
AVAILABLE BEFORE 8/27/2026

Senior Research Scientist, Biophysics (Contractor)


12-month contract | On-Site | South San Francisco, CA


A leading precision-oncology organization is seeking a Senior Research Scientist (Biophysics) to support small-molecule drug discovery. This hands-on role sits within a collaborative Lead Discovery group and focuses on biophysical and mechanistic characterization of small molecule/protein interactions.


What You’ll Do

  • Design and run SPR binding studies (Biacore S200, 8K ).
  • Conduct compound screening and mechanistic assays (nanoDSF, DLS, Spectral Shift).
  • Manage external CRO biophysics studies.
  • Analyze data, support SAR, and contribute to hit-too-lead/lead optimization.
  • Present results and prepare high-quality study reports.


What You Bring

  • PhD in biophysics, biochemistry, or related field.
  • 3 years of industry or relevant academic experience in small molecule biophysics.
  • Strong expertise in SPR and additional biophysical methods (TSA, DLS, NMR, ITC, etc.).
  • Excellent troubleshooting, communication, and organizational skills.
  • Ability to thrive in a fast paced, collaborative environment.
  • Curiosity, critical thinking, and a passion for impactful science.


Salary : $80 - $120

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