What are the responsibilities and job description for the Research Scientist (Biochemistry) position at Global Connect Technologies?
Job Title: Sr. Research Scientist – Biochemistry
Location: Onsite, Wilmington, DE
Position Overvie
wWe are seeking a highly skilled Sr. Research Scientist – Biochemistry to support drug discovery efforts through the design, development, and execution of biochemical and biophysical assays. This role will play a critical part in hit identification, validation, and mechanistic studies for small molecules and other therapeutic modalities
.
Key Responsibiliti
- esDesign, develop, and execute biochemical assays (e.g., FI, HTRF, FP) and biophysical assays (e.g., SPR, BLI, ITC, DS
- F)Conduct high-throughput screening (HTS) to evaluate compound libraries and characterize binding kinetics (IC₅₀, Kd, kon, kof
- f)Troubleshoot assay performance, optimizing for robustness, reproducibility, and scalabili
- tyAnalyze and interpret experimental data using tools such as GraphPad Prism and Geneda
- taSupport protein expression and purification workflows using chromatography techniques (affinity, ion-exchange, size-exclusio
- n)Operate and maintain lab instrumentation including plate readers and automated liquid handling syste
- msMaintain accurate documentation using electronic lab notebooks (ELN) and contribute to technical reports and presentatio
ns
Required Qualificati
- onsBachelor’s, Master’s, or Ph.D. in Biochemistry, Chemistry, Biophysics, Chemical Biology, or related fi
- eldStrong foundation in enzymology and assay developm
- entHands-on experience in protein purification and biochemical/biophysical characterizat
- ionProficiency with data analysis tools (GraphPad Prism, Genedata, or simil
- ar)Experience working in a laboratory setting with strong attention to detail and documentat