Principal Scientist

Are YOU eager to play a pivotal role in advancing genomic and proteomic assays to identify and analyze target biomarkers for clinical trials within a pharmaceutical laboratory setting? As a Principal Scientist, YOU will lead the development, validation, and execution of genomics and proteomics biomarker assays for clinical studies, ensuring all work aligns with GCP regulations and established SOPs.

This is a lab-based position with mandatory on-site presence at the Upper Providence, Pennsylvania (USA) laboratory site.

Key responsibilities include:

• Maintaining a state-of-the-art laboratory environment and acting as a technical expert in advanced genomics, transcriptomics and next-generation proteomics (NGP) technologies, including bulk RNA sequencing, single cell and single nucleus RNA sequencing, Olink PEA, Alamar-NULISA, qPCR, and dd-PCR.

• Performing method development, troubleshooting, validation, and sample analysis from method selection through data processing and delivery, with a strong focus on data quality, integrity, archiving, and compliance.

• Generating and interpreting high-quality data to support clinical studies, collaborating closely with Biomarker Leads and cross-functional teams to align assay support with biomarker strategies and project requirements.

• Serving as a subject matter expert for assay and study transfer to CROs and supporting the evaluation and integration of novel genomics and data analysis platforms.

• Managing complex method and data tasks, authoring scientific papers, presenting findings internally and externally, and providing clear, actionable recommendations for program strategy and next steps.

• Demonstrating strong project management skills by balancing multiple projects, meeting tight deadlines, and maintaining exceptional attention to detail and scientific rigor.

• Collaborating effectively across departments, building relationships with internal and external experts, and proactively solving project-related challenges with sound judgment and decision-making ability.

• Mentoring and training colleagues, fostering a culture of continuous learning, innovation, and operational excellence.

• Demonstrating knowledge of the drug development process, laboratory best practices, and safety regulations related to handling biological samples.

This role offers a unique opportunity to influence biomarker testing strategies, contribute to translational and clinical research, and advance your career in a collaborative, high-impact environment.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Master's Degree in relevant discipline (such as Biochemistry, Cell/Molecular Biology, Genetics, Genomics, Proteomics, or a related field).

• 5 years of relevant work experience

• Experience with genomic and proteomic analytical platforms (e.g., NGS, qPCR, dd-PCR, Olink PEA, Alamar-NULISA) is essential.

• Wet lab experience with Next Generation Sequencers (Illumina, ONT, PacBio) as well as in the design, troubleshooting, and implementation of NGS, qPCR, dd-PCR, Olink PEA, Alamar-NULISA, applications, or comparable high-content methodologies is highly valued.

• Experience interpreting data generated by various methods and assays such as NGS, Olink PEA, Alamar-NULISA, and other innovative genomics/proteomics techniques and commercial platforms is expected.

• Hands-on experience with automation platforms including Hamilton or equivalent systems, QiaCube, Mosquito, Dragonfly, F.A.S.T., and other automated liquid handling devices is added advantage.
  

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• PhD in relevant discipline (such as Biochemistry, Cell/Molecular Biology, Genetics, Genomics, Proteomics, or a related field).

• Extensive hands-on experience with Single cell/ Single nucleus sequencing platforms (e.g., 10XGenomics, BD Rhapsody, Parse) and single cell immuno-genomics workflows such as CITE-Seq and related applications.

• Knowledge and experience of genomics and proteomics workflow management platforms (e.g., DOMINO, Galaxy, CLC, DRAGEN) and other commonly used software.

• Knowledge of flow cytometry and histotechnology, enabling collaborations for cross-platform genomics projects such as CITE-Seq, TCR/BCR sequencing, and Spatial Transcriptomics.

• Exemplifies sound judgment and decision-making capabilities, particularly in prioritizing competing requests and objectives.

• Knowledge of regulatory requirements and a proven record of effective collaboration within cross-functional, matrixed environments alongside colleagues involved in all stages of clinical drug development, with the capacity to influence biomarker testing strategies.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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