Demo

Senior / Staff Software Engineer - Computational Chemistry / Molecular Dynamics

Genesis Molecular AI
San Mateo, CA Full Time
POSTED ON 1/14/2026
AVAILABLE BEFORE 2/11/2026

Genesis Molecular AI is building a world-class software team to solve problems in drug discovery through machine learning, biophysical simulation, and computational chemistry. We are looking for engineers excited to help develop new medicines and play a critical role in building out our software platform.


You will

  • Build and maintain complex computational chemistry workflows for drug discovery
  • Work closely with computational chemists and CADD scientists to productionize new computational methods for molecular property prediction
  • Help scale our data infrastructure to handle billions of datapoints and hundreds of thousands of parallel QM and molecular dynamics jobs


You are

  • A deep thinker who reasons from first principles, balances attention to detail with architectural thinking, and has an investigational curiosity to find the root cause of a problem
  • Comfortable working across all levels of the software stack, building intuitive APIs and libraries for computational chemists
  • Experienced working in the fields of computational chemistry and drug discovery
  • Experienced writing production code and driving projects to completion


What we offer

  • The opportunity to work on high impact tools and products that are immediately deployed to accelerate the discovery of new medicines
  • Strong technical coworkers in AI, software, and chemistry, who all have a powerful mix of intellectual curiosity and humility. The team reads and discusses 1-2 machine learning or chemistry papers every week to stay on top of the field and inspire new ideas
  • Competitive salary and equity. Medical, dental, and vision insurance, and a 401(k) program


About Genesis Molecular AI

Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company’s generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.


Genesis is headquartered in San Mateo, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.

Salary.com Estimation for Senior / Staff Software Engineer - Computational Chemistry / Molecular Dynamics in San Mateo, CA
$121,306 to $146,139
If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

What is the career path for a Senior / Staff Software Engineer - Computational Chemistry / Molecular Dynamics?

Sign up to receive alerts about other jobs on the Senior / Staff Software Engineer - Computational Chemistry / Molecular Dynamics career path by checking the boxes next to the positions that interest you.
Income Estimation: 
$146,673 - $180,130
Income Estimation: 
$176,149 - $220,529
Income Estimation: 
$97,257 - $120,701
Income Estimation: 
$123,167 - $152,295
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at Genesis Molecular AI

  • Genesis Molecular AI Burlingame, CA
  • About The Team Join a world-class team at the forefront of AI and biochemistry. At Genesis Molecular AI, we’re a tight-knit team of proven deep learning re... more
  • 14 Days Ago

  • Genesis Molecular AI San Diego, CA
  • Intern, Compound Management Genesis Molecular AI is pioneering artificial intelligence guided rational drug design to address severe unmet medical needs fo... more
  • 8 Days Ago

  • Genesis Molecular AI Burlingame, CA
  • Genesis Molecular AI is building a world-class software team to solve problems in drug discovery through machine learning, biophysical simulation, and comp... more
  • 9 Days Ago

  • Genesis Molecular AI San Mateo, CA
  • About the Team Join a world-class team at the forefront of AI and biochemistry. At Genesis Molecular AI, we’re a tight-knit team of proven deep learning re... more
  • 1 Day Ago


Not the job you're looking for? Here are some other Senior / Staff Software Engineer - Computational Chemistry / Molecular Dynamics jobs in the San Mateo, CA area that may be a better fit.

  • Genesis Molecular AI Burlingame, CA
  • Genesis Molecular AI is building a world-class software team to solve problems in drug discovery through machine learning, biophysical simulation, and comp... more
  • 9 Days Ago

  • Genesis Molecular AI Burlingame, CA
  • About The Team Join a world-class team at the forefront of AI and biochemistry. At Genesis Molecular AI, we’re a tight-knit team of proven deep learning re... more
  • 14 Days Ago

AI Assistant is available now!

Feel free to start your new journey!