Scientist 3, Discovery Oncology

The Opportunity

The Department of Discovery Oncology at Genentech is excited to announce an opportunity for a lab-based Scientist with a strong interdisciplinary background. This position will be part of the RAS-MAPK Signaling and Intervention Strategies Laboratory, which focuses on understanding oncogenic signaling mechanisms and developing novel therapeutic strategies targeting the Ras/MAPK pathway.

The ideal candidate will have deep expertise in cell biology and oncogenic signaling pathways. This position will focus on discovering new targets and mechanisms of action in oncogenic signaling. The successful candidate will integrate molecular biology, cell biology, and protein biochemistry to investigate differences in signaling mechanisms in normal and cancer cells. Working closely with drug discovery project teams, translational medicine, and clinical development teams, you will help identify new therapeutic hypotheses and advance discovery and development of transformative medicines.

Key responsibilities include:

• Interdisciplinary Collaboration: Work closely with internal experts across computational, research biology, and drug discovery disciplines to develop hypotheses and model systems that drive innovative therapeutic strategies. This will primarily be a wet-lab-based position.

• Supporting drug discovery projects: Perform cell biology and biochemistry experiments to characterize drug-like molecules and investigate their mechanisms of action.

• Translational Impact: Generate high-quality, original research that advances our understanding of cancer biology as well as contributing to the development of new therapies for oncologic indications.

Who You Are

• Educational Background: Ph.D. in Biochemistry, Cell Biology, or a closely related field. Postdoctoral experience is preferred, but not essential.

• Experience: Your record should reflect sustained high-impact publications and/or patents, and substantial progress on projects that have deepened our understanding of cancer biology.

• Technical Expertise: Demonstrated expertise in cell biology techniques including transfection and stable cell line generation, organoid culture, CRISPR/Cas9 gene editing and screening; Demonstrated expertise in molecular biology techniques including IP, qPCR, western blots, FACS, IHC, RNAseq, ChIP-seq and analysis; cancer research, and biochemistry.

Preferred

• Experience in the RAS-MAPK signaling pathway and induced proximity is a plus.

• Experience with or interest in leveraging AI/ML to accelerate research is a plus.

A fearless scientist who tackles difficult problems, continuously develops new skills, and applies any technique or method necessary to advance our understanding of human cancers and discover new intervention strategies.

If you are excited about working in a fast-paced, science-focused, and multi-disciplinary environment to uncover novel therapeutic targets for cancer and drive transformative medicines, we encourage you to apply. This role offers a unique opportunity to make a significant impact at the forefront of research and drug discovery at Genentech.

Relocation benefits are available for this posting.

The expected salary range for this position based on the primary location of California is $103,400 - $192,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.