Demo

Distinguished Scientist, Discovery Chemistry

Genentech and Careers
San Francisco, CA Full Time
POSTED ON 12/26/2025
AVAILABLE BEFORE 2/25/2026
THE POSITION

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech, a member of the Roche Group.

The Opportunity

We have an exciting opportunity for an experienced scientific leader and medicinal chemist to join our Small Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA. The successful candidate will be responsible for leading drug discovery project teams through various stages of therapeutic target identification, druggability, preferred mode-of-action assessment, hit-finding enablement, hit-to-lead, and lead optimization in a multi-disciplinary, team-based culture. They will have particularly deep expertise in the early stages of drug discovery projects and would be working closely with therapeutic area leaders to evaluate potential targets. The position will entail responsibilities for influencing drug discovery practices and interacting directly with various functions such as Biochemical and Cellular Pharmacology, Drug Metabolism and Pharmacokinetics, Pharmaceutical Sciences, Safety Sciences, and Structural Biology.


Who You Are

  • You will have a Ph.D. with 15 years of medicinal chemistry experience in industry in the design and synthesis of analogs for molecular targets by applying state-of-the-art structure-driven and property-based design principles with deep experience in establishing and implementing successful partnerships with contract research organizations (CROs).

  • You will demonstrate a strong record of accomplishments as noted by significant and creative contributions to the success of small-molecule projects.

  • Lead, mentor, and provide career development for department staff and influence medicinal chemistry teams.

  • You will convey strong verbal and written communication skills and an ability to work collaboratively in teams.

Preferred

  • Particular enthusiasm for mentoring colleagues across a wide range of experiences and disciplines is desired.

The expected salary range for the Distinguished Scientist position based on the primary location of South San Francisco, CA is $196,100 - $364,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are approved for this posting.

#LI-KC2

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

JOB FACTS
    Job Sub Category

    Research Biology

    Schedule

    Full time

    Job Type

    Regular

    Posted Date

    Oct 23rd 2025

    Job ID

    202510-127501

Salary : $196,100 - $364,100

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