Molecular Biologist (50534)

Position Objective: Provide services as a Molecular Biologist in support of the overall functions of the National Institute on Aging (NIA) within the National Institutes of Health (NIH).

The purpose of this position is to support research inside our laboratory regarding biomarker studies using Extracellular Vesicles (EVs) in large longitudinal study cohorts. The incumbent will conduct isolation of EVs from human (and potentially rodent) plasma and other biofluids using appropriate techniques. In addition, will conduct characterization of EVs by Nanoparticle Tracking Analysis, Light Microscopy, Western Blotting, and other techniques. In addition, will conduct ELISA-type immunoassays using various platforms (ELISA kits, Luminex, Mesoscale, SIMOA, etc.); will perform QC assessments; assemble data in spreadsheets; assist in analyzing and interpreting data; assist in preparing graphs, figures and manuscripts.

Duties and Responsibilities:

• Compile and analyze molecular or cellular experimental data and adjust experimental designs as necessary.
• Compile and analyze molecular or cellular experimental data and adjust experimental designs as necessary.
• Performs isolation of Extracellular Vesicles (EVs) from biological fluids (plasma, CSF, serum) and cell culture supernatant using established protocols
• Conducts immunoassays (Elisa or similar) to measure biomarkers
• Conducts EV characterization by Western Blots, Nanoparticle Tracking Analysis, Nanoview and similar methodologies
• Evaluate new technologies to enhance or complement current research.
• Perform quality control, validation, and other quality activities to verify performance of clinical assays.
• Maintain precise and complete records of all experimental activities, to include methodologies, instrumentation and findings for futrure reference. 1
• Input accurate record of all research activties and findings in in-house databases and repositories. 2
• Prepare routine status updates and outcome briefings to peer researchers and senior program executives. 4
• Provide routine activity updates and briefings to senior researchers and program executives. 3
• Prepare statistical packages of results and findings for use by other researchers and scientists. 5
• Maintain deep understanding of research methodologies and the latest trends and developments in molecular and celluar biological testing and research.
• Consult with diverse, cross-functional stakeholder groups to identify opportunities, develop problem statements and understand context to inform research strategies.
• Search scientific literature to select and modify methods and procedures.
• Collaborate with professional and academic societies, associations and organizations to identify new approaches to diagnostic testing and prepare recommendations for adoption.
• Produce final reports and presentations of experiments and findings for distribution internally among researchers and senior administrators.
• Write scholarly articles for publication in peer reviewed scientific journals.
• Develop and present original research findings and professional and scientific conferences and workshops.
• Review and edit papers, reports, presentations and articles produced by other researchers for distribution internally and externally.
• Conduct EV isolation using established laboratory protocols in plasma/serum samples from large cohorts, including but not limited to CHARIOT-PRO, HABS, BLSA and University of Basel cohort. Conduct immunoassays, including ELISA, Luminex,
• Mesoscale, SIMOA, etc. Characterize EVs by NTA, WB and other techniques. Record and organize data in spreadsheets.
• Prepare graphs, figures and tables based on data. Conduct statistical analysis. Interpret results and contribute to writing of publications.
• Meet with lab members to present updates and Clean Equipment

Basic Qualifications:

• PhD in Neuroscience, Molecular Biology, Miscellaneous Biology, or similar
• Good Laboratory Practice (GLP) Certification
• Skilled in Statistic packages such as R, SPSS
• Skilled with NIH POTS
• Experience in Western Blots, ELISA and immunoassays, Extracellular Vesicle characterization
• Experience in Extracellular Vesicle isolation and cell cultures
• Skilled in PowerPoint, Word, Excel

Preferred Qualifications:

• Ability to multi-task and pay close attention to detail.
• Excellent analytical, organizational and time management skills.
• Strong communication skills, both oral and written.

*This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.  

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job us at recruiting@gapsi.com. You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.

Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other characteristics protected by law.

Salary : $100,000 - $110,000