What are the responsibilities and job description for the Senior Research Associate, Protein Science position at Flagship Pioneering?
Company Description
Flagship Labs 110 Inc. (FL110) is a privately held, early-stage technology company developing a fully integrated, end-to-end platform to enable next generation proteomics. Our platform integrates groundbreaking innovations in bioengineering, machine learning, and custom microelectronics to offer a level of precision and insight never before achieved.
FL110 is backed by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. We are uniquely cross-functional and collaborative. Our teams thrive in unstructured and creative environments. Therefore, we seek individuals with an inclusive mindset and a diversity of thought.
If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, please apply.
About the Role
We are seeking a highly motivated Senior Research Associate with experience in recombinant protein expression, purification, and characterization to support the development of FL110’s next-generation protein sequencing platforms and products.
In this role, you will design, execute, and optimize protein production workflows from construct design through biochemical and biophysical characterization. You will work in a collaborative, interdisciplinary environment where teams rapidly interpret and respond to experimental results to guide platform development. The ideal candidate is an organized and creative experimentalist who enjoys troubleshooting challenging protein targets and contributing to new technologies.
Basic Requirements
Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $81,000 - $107,250. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL110 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL110's good faith estimate as of the date of publication and may be modified in the future.
Flagship Labs 110 Inc. (FL110) is a privately held, early-stage technology company developing a fully integrated, end-to-end platform to enable next generation proteomics. Our platform integrates groundbreaking innovations in bioengineering, machine learning, and custom microelectronics to offer a level of precision and insight never before achieved.
FL110 is backed by Flagship Pioneering, which brings the courage, long-term vision, and resources needed to realize unreasonable results. We are uniquely cross-functional and collaborative. Our teams thrive in unstructured and creative environments. Therefore, we seek individuals with an inclusive mindset and a diversity of thought.
If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, please apply.
About the Role
We are seeking a highly motivated Senior Research Associate with experience in recombinant protein expression, purification, and characterization to support the development of FL110’s next-generation protein sequencing platforms and products.
In this role, you will design, execute, and optimize protein production workflows from construct design through biochemical and biophysical characterization. You will work in a collaborative, interdisciplinary environment where teams rapidly interpret and respond to experimental results to guide platform development. The ideal candidate is an organized and creative experimentalist who enjoys troubleshooting challenging protein targets and contributing to new technologies.
Basic Requirements
- BS or MS degree in Biochemistry, Molecular Biology, or a related field, with 4 years of research experience in an academic or industry laboratory.
- Extensive hands-on experience in bacterial recombinant protein expression and purification, spanning the full workflow from DNA construct design and transformation through chromatographic purification using affinity, ion-exchange, and size-exclusion techniques.
- Proficiency with ÄKTA purification systems, including designing and executing protein purification methods.
- Familiarity with analytical techniques used to assess recombinant protein quality.
- Strong organizational skills and the ability to document experimental work in an ELN and maintain records in an electronic LIMS.
- Ability to independently design, execute, troubleshoot, and interpret experiments related to protein expression, purification, and stability.
- Hands-on work with nanopore-forming proteins or related membrane protein systems.
- Familiarity with automation in a biochemistry setting.
- Experience developing functional assays to evaluate protein activity or performance.
- A track record of improving protein yield through construct and protocol optimization.
- Design, express, purify, and characterize soluble and membrane proteins.
- Develop and optimize expression and purification strategies for challenging protein targets.
- Design and evaluate new protein constructs and variants informed by experimental results.
- Characterize proteins using biochemical and biophysical methods to assess purity, stability, and function.
- Collaborate with experimental and computational teams to interpret results and guide future protein and nanopore designs.
- Document experimental workflows and contribute to shared lab knowledge and technical documentation.
Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.
At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $81,000 - $107,250. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL110 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL110's good faith estimate as of the date of publication and may be modified in the future.
Salary : $81,000 - $107,250