Senior Manager, IT Infrastructure & Operations

Job Title: Senior Manager, IT Infrastructure, Systems & Operations

Location: Princeton, NJ (Hybrid Flexibility)

Reports To: Senior Director, Global Head of Information Technology

About F2G

F2G is a clinical-stage biopharmaceutical company focused on the discovery and development of novel therapies to treat life-threatening invasive fungal infections. F2G has discovered and developed a completely new class of antifungal agents called the orotomides. The orotomides have a distinct mechanism of action, selectively targeting fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. This differentiates the orotomides from the currently marketed antifungal agents. Olorofim (formerly F901318) is F2G’s leading candidate from this class and has fungicidal activity against a broad range of mold infections, including a variety of rare and resistant molds that cause life-threatening infections for which current therapies have limitations or are ineffective.

F2G has completed a Phase 3 randomized clinical study to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with Invasive Fungal Disease Caused by Aspergillus Species and received positive topline data in June 2026. A previous Phase 2b open-label study of olorofim focused on rare and resistant invasive fungal infections including invasive aspergillosis (including azole-resistant strains), coccidioidomycosis and scedosporiosis (including lomentosporiosis). Olorofim has received orphan drug status from the European Medicines Agency and orphan drug status, Qualified Infectious Disease Product (QIDP) designation, and Breakthrough Therapy designation from FDA.

F2G is headquartered in the UK with subsidiaries in the US and Austria.

Our Vision

F2G’s vision is to bring to market safe, convenient, and effective novel antifungal agents to challenge a global unmet need for therapies that are active against resistant infections and also against pathogens which have historically been difficult to treat. Olorofim is the first novel anti-fungal treatment developed in the past 20 years and is the only antifungal medication ever to be awarded a Breakthrough Therapy Designation for multiple designations by the FDA. F2G believes that olorofim, and subsequent agents, will address some of the many challenges which face the treating physician and the patient with invasive fungal infections.

The Role:

• F2G is in a transformational period where we are accelerating data, digital and technology to advance our mission and capabilities. We are seeking a hands-on IT Manager who will serve as the primary IT point of contact for the site, providing responsive support and taking ownership of issues through resolution.
• The role will focus on End-User IT Support, troubleshooting and resolving hardware (including laptops, smartphones, tablets, peripherals and conference room AV), software, network and connectivity issues; managing Entra ID identities, user provisioning and offboarding; and maintaining accurate Service Desk documentation.
• The role will own the end-user device lifecycle across computers and mobile devices, including procurement, inventory, shipping and returns, provisioning, configuration, support, patching and retirement. This includes configuring and maintaining Microsoft Intune and Windows Autopilot for secure remote/zero-touch provisioning of Windows devices, as well as the MDM platform used to enrol, configure, secure and manage smartphones and tablets (including BYOD), ensuring all endpoints remain compliant with F2G policies.
• The role will help maintain a secure and compliant IT environment, including endpoint and mobile device security, identity and access controls, security policies, threat response and compliance requirements.
• Contributes to the continuous improvement of F2G’s technology stack by identifying opportunities to simplify, standardize, automate and modernize systems and processes; evaluating new technologies and capabilities; and recommending improvements that enhance scalability, user experience, security, resilience and operational efficiency.
• Will ensure continuous training and enablement through new-hire IT onboarding and maintaining a knowledge base of how-to guides and FAQs. Support should not only resolve immediate issues, but identify root causes, implement sustainable solutions, document them, and help prevent recurrence through user education and self-service support portal.
• Contributes across Tier 1/2/3 and VIP support, coordinating with internal teams, MSPs and technology vendors when escalation is required, while maintaining ownership through resolution.
• Participates in access control, documentation, auditability, security, privacy, backup and recovery, business continuity and disaster recovery, and CSV/CSA activities where relevant.
• Supports F2G’s transformational period by ensuring the IT environment is scalable, resilient and inspection-ready; strengthening business continuity, access controls, system documentation, change management and support processes; and partnering with Quality and business functions on CSV/CSA and regulated systems where applicable.
• This is a hands-on role requiring strong technical troubleshooting, ownership and continuous improvement, balancing rapid user support with proactive improvement of F2G’s technology environment and reliable, long-term solutions.

Required Qualifications:

• Bachelor’s degree in Computer Science, Engineering, Information Technology, or a related discipline, or equivalent relevant experience.
• Minimum 5 years of experience in IT support, systems administration, end-user computing, or a related role.
• Strong hands-on experience supporting a Windows and mobile environment, including laptops, smartphones, tablets, hardware troubleshooting, software configuration, network connectivity, peripherals, and conference room technology.
• Hands-on experience with Microsoft Intune and Windows Autopilot for Windows endpoint management, including remote/zero-touch provisioning, application deployment, configuration and compliance policies, patching, troubleshooting, and ongoing device lifecycle management.
• Experience with MDM platforms for smartphones and tablets, including device enrolment, configuration, security and compliance policies, application deployment, remote support, and device retirement/wipe.
• Experience with Microsoft 365, Entra ID, identity and access management, SSO/MFA, user provisioning and offboarding, endpoint protection, Azure, and related Microsoft technologies.
• Strong troubleshooting and root-cause analysis skills, with the ability to resolve issues quickly while implementing sustainable solutions that prevent recurrence.
• Experience documenting incidents and resolutions and building knowledgebase, how-to, and self-service content for users.
• Working knowledge of IT security, access control, data protection, endpoint security, and relevant compliance frameworks such as NIST, GDPR, HIPAA, SOX, and HITRUST.
• Strong communication and customer-service skills, with the ability to explain technical issues clearly to non-technical users and take ownership of issues through resolution.
• Highly organized, self-directed, and comfortable managing multiple priorities in a fast-moving environment, including occasional out-of-hours support when required.

Additional Responsibilities and Accountabilities:

• At least once a week on-site Princeton office

Engage with us on our LinkedIn page as well at https://www.linkedin.com/company/f2g/