What are the responsibilities and job description for the Director, Head of Chemistry position at Evercrisp Biosciences?
About Us
Evercrisp Biosciences, founded by world-renowned scientists who bring expertise and proprietary technology to the company, is currently operating in stealth mode with a substantial Series A commitment from Apple Tree Partners (ATP) to take the company from discovery to proof of concept. Evercrisp is initially focused on high-confidence, genetically validated but 'difficult to drug' targets in areas of high unmet need where genome editing can make a significant difference. At Evercrisp, innovation, collaboration, and commitment to making a significant impact on human health guide our work.
The Job
As the Head (Director) of Chemistry, you will play a pivotal role in steering our in-house chemical biology and analytical team through the intricate journey from early-stage research through preclinical animal models and onwards. Your leadership will be instrumental in managing contract research organizations (CROs) and full-time employees (FTEs) across various disciplines to support guideRNA synthesis, medicinal and linker chemistry efforts. This role requires a visionary who can also lead the strategy for the design of our gene editing platform to enable efficient in vivo editing efforts.
Key Responsibilities:
- Lead and manage the in-house team, fostering an environment of innovation, efficiency, prioritization, and scientific rigor.
- Strategize, plan, and oversee the synthesis, purification, and characterization of guideRNAs, compounds and linkers.
- Direct development and optimization of the RNP-based platform for in vivo delivery
- Manage relationships and projects with various CROs (and FTEs), ensuring high-quality deliverables within timelines and budgets.
- Collaborate closely with cross-functional teams, including Computational Biology, Protein Science, Cell Biology, and Translational to ensure integrated progress towards company milestones.
- Drive the scientific strategy for chemistry efforts, staying abreast of the latest advancements in the field to ensure Evercrisp remains at the cutting edge of gene editing.
- Lead by example, cultivating a culture of scientific excellence, teamwork, and dedication to impacting human health.
Qualifications:
- PhD in Chemistry, Biochemistry, or a related field with a strong focus on synthetic organic chemistry or medicinal chemistry.
- At least 5 years of relevant industry experience, with a proven track record in leading chemistry teams and projects in the biotech or pharmaceutical sector.
- Demonstrated expertise in the design of modified oligonucleic acids for in vivo delivery.
- Extensive experience managing CROs and FTEs for the synthesis and analysis of biological molecules, compounds, and linkers.
- Strong leadership skills with the ability to inspire, motivate, and guide teams towards achieving scientific and organizational goals.
- Excellent communication and interpersonal skills, capable of fostering collaborations and effectively presenting complex scientific data and strategies to internal and external stakeholders.
- A strategic thinker with a problem-solving mindset and the ability to adapt to the fast-paced, evolving nature of startup environment.
Why Evercrisp?
Joining Evercrisp means becoming part of a team dedicated to making a lasting impact on the future of genetic medicine. We offer a dynamic, innovative, and supportive environment where your work will directly contribute to groundbreaking advancements in CRISPR-based technologies. At Evercrisp, we value diversity, encourage professional growth, and provide competitive benefits and compensation.
Evercrisp is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
