Off-Target Biology and Genomics Scientist - Gene Therapy

Company Description

The work we do at Eurofins Professional Scientific Services matters, and so do our employees. At Eurofins PSS, we put a focus on your professional growth. We provide our employees with the ability to break into the biopharmaceutical industry and grow from the bottom up. We have the supportive teams and tools available to invest in you while also affording your work-life balance and a competitive benefits package.

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic, and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery of pharmacology, forensics, CDMO, advanced material sciences, and in the support of clinical studies.

If you’re looking for a rewarding career, a place to call home, apply with us today

Job Description

• Lead and execute genomic safety assessment packages for gene editing therapeutics, spanning off-target discovery, verification/validation, and genomic integrity characterization.
• Apply and evaluate a range of off-target discovery approaches, including in silico tools (CALITAS, CRISPRMe, CasOFFinder), biochemical methods (SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq), and cell-based assays (GUIDE-seq, INDUCE-seq).
• Drive off-target verification and validation using amplicon-based sequencing approaches such as AmpSeq, rhAmpSeq, and hybrid capture sequencing.
• Characterize genomic integrity using orthogonal methods including karyotyping, optical genome mapping, and WGS.
• Assess genotoxicity potential of next-generation genome engineering modalities (base editors, prime editors) using modality-appropriate off-target assessment strategies.
• Contribute to or lead novel assay development efforts to interrogate emerging genome editing modalities (Gen 5 )
• Integrate biodistribution data to guide tissue selection for off-target verification studies

Qualifications

Minimum Required Qualifications:

• B.S. in genomics, molecular biology, biochemistry, or a related field with 5 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. M.S. in genomics, molecular biology, biochemistry, or a related field with 3-7 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. Ph.D. in genomics, molecular biology, biochemistry or related field with 2-4 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics.
• Proficiency with CRISPR-based genome editing and familiarity with a broad range of off-target discovery platforms.
• Experience with next-generation sequencing workflows and data interpretation.
• Familiarity with emerging modalities such as base editing and prime editing, and their associated genotoxicity considerations.
• Strong track record of scientific problem-solving, with experience in assay development being a plus.
• Excellent written and verbal communication skills; ability to present complex data to cross-functional teams.
• Ability to work independently and as a part of a team, self-motivation, adaptability, and a positive attitude.

Preferred Qualifications:

• Experience with optical genome mapping (Bionano platform).
• Familiarity with regulatory expectations around genomic safety packages for IND/BLA submissions.
• Experience with human diversity-dependent off-target discovery approaches (e.g., ONE-seq).
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information

The position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to apply

What to Expect in the Hiring Process:

• 10-15 Minute Phone Interview with Regional Recruiter
• 45-60 Minute Virtual Interview with Manager and/or Group Leader
• 45-60 Minute In-Person Meeting for a Casual Discussion of the Role

What We Offer:

• Excellent full-time benefits, including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Yearly goal-based bonus & eligibility for merit-based increases
• Annual Compensation is $104,000 - $112,320, depending on education and experience 

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.