In Vivo Pharmacologist- Immunology

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At Lilly’s Biotechnology Center in San Diego, the in vivo immunology group contributes to the advancement of the immunology portfolio by creating innovative in vivo models to interrogate complex biology. Our collaborative efforts span across both discovery and development organizations, working closely with scientists specializing in immunology, bioengineering, chemistry, biomolecule formulation and developability, genetic medicines, and other related disciplines to drive immunology research and therapeutic development.

We seek an in vivo scientist who will lead research studies focused on understanding immunological mechanisms using advanced in vivo models to enable drug discovery efforts. The ideal candidate will demonstrate expertise in humanized mouse systems, particularly with CD34 hematopoietic stem cell engraftment. Responsibilities include model development and execution, analyzing data, and collaborating with multidisciplinary teams to advance therapeutic development. Strong experience with immunophenotyping, in vivo assay development, and interpretation of preclinical data is essential. Strong interpersonal skills and the ability to excel in a highly collaborative environment are vital.

Responsibilities:

• Provide strong scientific and technical leadership to establish and innovate in in vivo models to interrogate mechanisms and pathways relevant to the discovery of novel treatments for autoimmune diseases and related pathologies.
• Be hands-on in the laboratory to leverage and develop in vivo and in vitro systems to generate critical data supporting new and existing programs. Must be skilled with human CD34 hematopoietic stem cell engraftment.
• Function independently, work within a team-oriented lab environment and communicate results to cross functional discipline teams.
• Provide supervision and mentoring to 1-2 scientists, performance evaluations, and career development.
• Requirement for accurate record keeping, independent data analysis, and reporting of data in written and oral formats. Will perform work in full compliance with Lilly Research Policies and complete all required training activities in the timeframe specified.

Basic Qualifications/Requirements:

• Ph.D. in physiology, immunology, biology, pharmacology, or a closely related field
• 1- 2 years' experience with in-vivo capabilities and human CD34

Additional Skills/Preferences:

• Strong/extensive in vivo capabilities
• Skilled in the art of human CD34 hematopoietic stem cell engraftment into mice and execution of downstream studies.

• Proficient in cell isolation, cell culture, and immune cell differentiation procedures
• Knowledgeable with ex vivo sample assays and analyses (e.g. ELISA, RNA isolation, Nanostring)
• Familiarity with FACS and immunophenotyping
• Ability to prioritize activities across multiple projects independently and effectively while demonstrating initiative and appropriate risk taking.
• Excellent communication and organizational skills are required to present findings in internal and external forums.

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Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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