What are the responsibilities and job description for the Senior Advisor Biotransformation position at Eli Lilly and Company?
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Senior Advisor Biotransformation
The Biotransformation group within the multidisciplinary DMPK organization at Eli Lilly and Company is seeking a candidate to lead and implement biotransformation studies in drug discovery and development. The selected candidate will be responsible for the conduct and oversight of in vivo and in vitro metabolism packages, investigations, interpret results, propose/complete biotransformation experiments to solve important mechanistic biotransformation questions and communicate effectively with DMPK, project teams and management. Duties will include oversight/guidance of external (CRO) metabolism studies, performance of in-house non-routine laboratory work and collaboration across various DMPK fields. We are seeking a candidate with expertise in radiolabel studies, hands-on experience performing in vivo and in vitro biotransformation studies, including mass spectrometry, structure identification, sample extraction and analytical method development.
Job Responsibilities
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$142,500 - $228,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
Senior Advisor Biotransformation
The Biotransformation group within the multidisciplinary DMPK organization at Eli Lilly and Company is seeking a candidate to lead and implement biotransformation studies in drug discovery and development. The selected candidate will be responsible for the conduct and oversight of in vivo and in vitro metabolism packages, investigations, interpret results, propose/complete biotransformation experiments to solve important mechanistic biotransformation questions and communicate effectively with DMPK, project teams and management. Duties will include oversight/guidance of external (CRO) metabolism studies, performance of in-house non-routine laboratory work and collaboration across various DMPK fields. We are seeking a candidate with expertise in radiolabel studies, hands-on experience performing in vivo and in vitro biotransformation studies, including mass spectrometry, structure identification, sample extraction and analytical method development.
Job Responsibilities
- Independently design, conduct, troubleshoot and provide oversight of “cold” and radiolabeled in vitro and in vivo preclinical and clinical biotransformation studies for small molecules and new modalities (i.e. peptides).
- Use mass spectrometry to assess in vitro and in vivo biotransformation liabilities to inform drug design.
- Design, conduct and guide critical problem focused experiments involving sample extraction, separation techniques, LC/MS and radiometric metabolite profiling for the identification and quantification of drug candidates and metabolites from in vitro and in vivo biological matrices.
- Evaluate and implement innovative technologies and aid in developing strategies to evolve biotransformation capabilities within the department.
- Integrate data across teams to create a rational interpretation of drug metabolism/clearance.
- Mentor and supervise junior scientific personnel as needed.
- Apply regulatory guidance in biotransformation (ie. MIST, metabolite DDI, reactive metabolites).
- Work collaboratively in a fast-paced work environment collaborating both internally and externally (CRO’s).
- Author and review scientific reports and original scientific manuscripts.
- Be involved in the external scientific community.
- Effectively communicate interpretation of results across DMPK, to project teams and to management.
- PhD in organic, medicinal, natural products or analytical chemistry
- 7 years of biotransformation experience
- Experience with conducting accelerator mass spectrometry (AMS) studies (ABA, mass balance and radioprofiling)
- Possess an understanding of clearance mechanisms, and enzymes involved in biotransformation.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$142,500 - $228,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
Salary : $142,500 - $228,800
