Demo

Principal Engineer, Software - Image Analysis

eikontherapeutics
Millbrae, CA Full Time
POSTED ON 1/8/2026
AVAILABLE BEFORE 3/8/2026

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position 

The Principal Engineer for Analysis Software will join a multi-disciplinary engineering team that develops systems handling multiple high-throughput (PB/week) high-content imaging data streams.  The position's primary responsibility will be to design and support mission-critical computational pipelines to analyze proprietary microscopy data, in collaboration with the larger Engineering, Research and Information Technology teams. 

About You 

You are a software engineer who enjoys discussing architecture and data design with senior peers. You actively code and collaborate while keeping team goals aligned with business objectives. 

What You will Do

  • Build reliable, flexible data processing and data storage architecture to organize biological and microscopy datasets and extract features from Eikon’s proprietary data.
  • Work with data lakes and data pipelines to organize, clean, and serve scientific data for diverse use cases.
  • Maintain essential computational pipelines for ongoing scientific research.
  • Define and evolve the engineering system architecture vision to support system features and user-facing capabilities.
  • Lead a small team as technical lead.
  • Characterize and communicate design trade-offs to technical and non-technical audiences.
  • Collaborate with Product and Program Management to develop high-level roadmaps for key software deliverables satisfying defined system-level business needs and user acceptance tests.
  • Stay up to date with emerging trends and advancements in machine learning, distributed systems, cloud technologies, and software engineering practices, and evaluate their potential impact on our internal products. 

Qualifications 

  • Bachelor's degree with 15 years of relevant experience or a master's degree with 12 years of relevant experience or a PhD with 8 years of relevant experience in Computer Science, Software Engineering or a related field.
  • Prior experience building and supporting reliable production systems, in Databricks or a similar platform.
  • Strong proficiency in React, TypeScript, Postgres and Python. 
  • Experience in multiple strongly typed languages such as C , C# or Java.
  • Successful track record designing software and systems architecture, including API and database design, commercial application development, cloud services, and DevOps practices.
  • Experience with architecting and building analysis software in the biotech field.
  • Excellent verbal and written communication skills, ability to bridge the gap between scientific users and engineers and developers. 
  • Team-oriented, flexible, able to adapt to rapidly evolving goals and challenges.  
  • Demonstrated leadership skills in a changing organization with evolving processes. 

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:​

  • 401k plan with company matching​
  • Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)​
  • Mental health and wellness benefits​
  • Weeklong summer and winter holiday shutdowns​
  • Generous paid time off and holiday policies​
  • Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies ​
  • Enhanced parental leave benefit​
  • Daily subsidized lunch program when on-site​

The expected salary range for this role is $230,000 to $251,750 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.

Salary : $230,000 - $251,750

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