Downstream Scientist

Job Number: 26-00643

Be part of a company that delivers life-changing healthcare solutions. ECLARO is looking for a Downstream Scientist for our client in East Syracuse, NY.

ECLARO’s client is a leader in the Biopharmaceutical Industry, providing quality, innovative, and affordable medicines that make a difference in the lives of patients all over the world. If you’re up to the challenge, then take a chance at this rewarding opportunity!

Position Overview:

• The primary role of the Downstream Scientist is to design and execute laboratory experiments in the development, optimization, characterization, and scale-up of biologics downstream purification processes to support early process development through TOX and tech transfer to manufacturing.
• This role requires strong technical expertise, independent experimental design, and the ability to manage project deliverables while collaborating cross-functionally with other teams.
• The role is a combination of laboratory- and office-based work.
• The Scientist will execute laboratory studies and author documentation, including protocols, technical transfer documents, batch records, SOP’s and reports.
• The Scientist is expected to follow detailed GLP / GMP procedures and safety requirements.
• The Scientist will be a subject matter expert working in a team environment and will interact with other functional departments.
  
  

Responsibilities:

• Design and execute downstream purification strategies for biologics, including monoclonal antibodies, recombinant proteins, and other modalities.
• Lead process development activities involving chromatography (Protein A, ion exchange, HIC) and filtration (UF / DF, TFF).
• Independently plan experiments, analyze data, and draw scientifically sound conclusions to guide process decisions.
• Scale up purification processes and support technology transfer to manufacturing teams.
• Serve as a technical lead for client projects, ensuring timelines, quality, and deliverables are met.
• Author and review technical documentation including development reports, protocols, SOPs, and tech transfer documents.
• Troubleshoot complex purification challenges and implement innovative solutions.
• Ensure compliance with internal and regulatory quality systems.
• Collaborate with upstream, analytical, and manufacturing teams to integrate process development activities.
• Mentor junior scientists and associates, providing technical guidance and training.
• Perform routine laboratory activities including sample management, instrument maintenance and calibration, inventory and ordering of supplies, general housekeeping, and other related activities.
  
  

Qualifications:

• Demonstrated scientific knowledge and laboratory skills in downstream purification (chromatography, dead-end and depth filtration, centrifugation, tangential flow ultrafiltration / diafiltration, viral inactivation and viral filtration) is preferred.
• Effective technical communication skills in written and verbal presentation format are essential.
• Demonstrated ability to work in fast paced environment in a timely manner, with minimal supervision.
• Degree in Biology, Chemistry, Biochemical or Chemical Engineering, or equivalent area of related industry experience in biologics downstream manufacturing or manufacturing technology: B.Sc. / B.Eng. with 3-5years, M.Sc. / M.Eng. degree with 2-4 years, or Ph.D. degree with 0-2 years of relevant industry experience.
  
  

If hired, you will enjoy the following ECLARO Benefits:

• 401k Retirement Savings Plan administered by Merrill Lynch
• Commuter Check Pretax Commuter Benefits
• Eligibility to purchase Medical, Dental & Vision Insurance through ECLARO
  
  

If interested, you may contact:

Paul Quibuyen

Christian.Quibuyen@eclaro.com

646-695-2942

Paul Quibuyen | LinkedIn

Equal Opportunity Employer: ECLARO values diversity and does not discriminate based on Race, Color, Religion, Sex, Sexual Orientation, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status, in compliance with all applicable laws.