What are the responsibilities and job description for the Principal Computational Chemist – Computational Drug Design (CADD) position at Discover International?
Principal Computational Chemist – Computational Drug Design (CADD)
Location: Boston, MA (Hybrid)
Full-Time
We are seeking an experienced computational medicinal chemist to join a dynamic, early-stage biotech team focused on advancing small molecule therapeutics. This role offers the opportunity to leverage physics-based simulations, AI/ML, and structural biology to drive drug discovery programs from hit identification through lead optimization.
What You’ll Do:
- Lead computational design of small molecule therapeutics, integrating simulation, structural, and assay data to inform project decisions.
- Apply and improve advanced computational approaches, including physics-based simulations and AI/ML, across all stages of drug discovery.
- Collaborate closely with cross-functional teams including medicinal chemistry, structural biology, and computational development.
- Mentor junior scientists and interns, building computational knowledge across the organization.
What We’re Looking For:
- PhD in computational chemistry, physical or organic chemistry, physics, or related field.
- 5 years of experience in computer-aided drug design or related biotech/pharma roles, with a track record of advancing small molecule projects.
- Expertise in physics-based simulations, AI/ML, and generative computational approaches.
- Strong programming skills (Python, R, C ) and experience with molecular simulation packages (AMBER, OpenMM, NAMD, Gromacs).
- Excellent collaboration, communication, and organizational skills.