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Manager, Supply Chain Planning

Denali Therapeutics
South San Francisco, CA Full Time
POSTED ON 7/20/2026
AVAILABLE BEFORE 9/3/2026
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Successful supply chain management is a cornerstone of Denali’s strategy. The Clinical Supply Chain Planner will lead and coordinate all forecasting, planning, and supply chain strategy activities for Denali’s clinical programs. This role will oversee all aspects of the planning process including demand forecasting, supply planning, and inventory management strategy for GMP materials. The Supply Chain function sits within Technical Operations and therefore interfaces heavily with CMC, Manufacturing, QA, Regulatory, Clinical Operations, and Finance. As Denali continues to develop its portfolio, this role will have the opportunity to help define and influence the long-term supply chain strategy.

Key Accountabilities/Core Job Responsibilities

  • Act as Supply Chain Lead for Denali’s clinical products including developing the supply chain strategy, demand and supply planning, and IRT strategy development
  • Execute scenario plans and develop recommended production and inventory management strategies
  • Serve as primary supply chain contact with internal and external stakeholders
  • Work cross-functionally with CMC, Development, and Finance departments to support program development
  • Proactively identify and troubleshoot issues to prevent missed timelines
  • Communicate program status both verbally and through written documents and reports
  • Drive continuous operational performance improvement efforts

Qualifications/Skills

  • Typically requires a Bachelor’s degree in Life Sciences/Engineering/Operations/Supply Chain or related field and 8 years of work experience to include 3 years in clinical supply chain planning in the Life Sciences.
  • Experience leading business process definition/improvement is strongly preferred
  • Skilled in using influence management to drive project success
  • Demonstrated ability to work accurately, meet timelines and handle multiple priorities
  • Capable of responding flexibly to changing prioritization in a dynamic environment
  • Strong interpersonal skills and ability to work with others in a positive “can do” and collaborative manner
  • Strong verbal and written communication skills
  • Advanced analytical capabilities with proficiency in Excel, Word, and PowerPoint
  • Requires working knowledge of cGMP and regulations applicable to the FDA and comparable international regulatory agencies.

Salary Range: $135,000.00 to $175,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

Salary : $135,000 - $175,000

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