Associate Scientist, Bioassay Development

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

This position develops, optimizes, and establishes state-of-the-art potency assays for our diverse pipeline of large molecule biotherapeutics with ligand-based and cell-based bioassays to characterize activity and potency of a variety of modalities including antibodies and Fc-fusion proteins as well as oligonucleotide-conjugates and virus-based gene therapies.

Key Accountabilities/Core Job Responsibilities:

• Independently perform bioassays to support cell and plate-based (ELISA, ENZYME ACTIVITY) development for late stage molecule

• Assist in the development, optimization, and qualification of assays for product release and stability testing as well as characterization of biological activity.

• Support study sample testing, analysis and maintain complete and accurate records and contribute to continuing process improvement

• Evaluate, characterize, and document critical reagents to meet QC standards

• Coordinate parallel tasks across multiple projects and prioritize deliverables to meet departmental and organizational goals.

• Promote innovation and explore novel analytical techniques or technology.

Qualifications/Skills:

• BS with 3 years of industry experience or an MS 1 years relevant experience in the industry

• Experience in developing and optimizing bioassays using cell based assay, ELISA, HTRF, Enzyme activity, Enzyme Kinetics, Octet is required.

• Proficient in aseptic technique, mammalian and primary cell handling

• Proficient in data analysis with Excel and statistical tools such as GraphPad Prism, SoftMax Pro, and PLA 3.0 .

• Familiar with electronic notebooks and documentation workflows.

• Ability to balance competing priorities and thrive in a dynamic, fast-paced environment

• Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills

• Excellent oral and written communication skills

• Motivated, detail-oriented, naturally curious individual with a creative approach to scientific problem solving and a burning desire to help patients with neurodegenerative diseases.

Salary Range: $107,000.00 to $131,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.