Senior Medical Director, Clinical Development

Senior Medical Director, Clinical Development

Damora Therapeutics has hubs in Waltham, MA and San Francisco, CA, and is open to remote hiring.

About Us

Damora Therapeutics is an innovative biotechnology company that aims to fundamentally redefine care for people with hematologic disorders. We are advancing a new generation of biologics to treat mutant calreticulin (mutCALR)-driven myeloproliferative neoplasms, including essential thrombocythemia and myelofibrosis, where there is significant medical need for new disease-modifying treatments. With multiple programs with best-in-class potential on track to enter clinical development in 2026, our goal is to rapidly bring forward optimized treatments with broad mutation coverage and exceptional convenience to dramatically improve patient outcomes.

The Role

We are seeking a Senior Medical Director, Clinical Development to play a critical leadership role in the design, execution, medical oversight and interpretation of our first-in-human clinical trials. This individual will serve as the medical reference on the study team and a key strategic partner to Clinical Operations, Translational Science, Regulatory, Biometrics and Safety, with significant responsibility for study-level strategy, medical leadership and cross-functional execution.

The Senior Medical Director will independently serve as medical monitor for one or more studies, contribute to dose-escalation and development strategy decisions, lead the clinical content of key clinical and regulatory documents, and provide medical leadership across internal governance and cross-functional forums. Program-level strategy decisions remain with the Vice President, Clinical Development. This role contributes to them and guides the study team through the study-level decisions that follow.

This role reports to the Vice President, Clinical Development.

What You’ll Do

Clinical Development Leadership & Trial Execution

• Serve independently as medical monitor on one or more studies in hematologic malignancies.
• Contribute strategically to the clinical development plan for mutCALR-targeting antibodies, including study design, dose-escalation strategy and data interpretation.
• Guide the study team through study-level strategic decisions, framing options and trade-offs and escalating program-level questions to the senior team.
• Lead, support and oversee the execution of clinical development and study activities.
• Drive dose-escalation and study conduct decisions through real-time review of emerging safety, PK/PD, biomarker and clinical data, including eligibility and toxicity management.
• Lead the clinical contribution to protocols, amendments, investigator brochures, informed consent forms, clinical study reports and regulatory briefing materials.

Cross-Functional Program Leadership

• Serve as a core medical leader across cross-functional program teams, partnering closely with Clinical Operations, Translational Medicine, Regulatory, Biometrics and Safety.
• Provide leadership, build consensus and coordinate action plans across functions to ensure a uniform, aligned operational approach and to resolve study-related issues.
• Collaborate with Translational and Preclinical teams to integrate biomarker and mechanistic hypotheses into clinical studies and broader development strategy.
• Proactively identify and address medical, scientific and operational risks and gaps.
• Foster a collaborative, engaging and high-performing team environment, and mentor clinical scientists and other study team members.

Medical Oversight, Data Review & Communication

• Serve as the medical reference in the cross-functional team, ensuring the medical relevance of clinical data.
• Lead ongoing review and interpretation of clinical data, including safety, efficacy, PK/PD and exploratory biomarkers, in partnership with Drug Safety on serious adverse event assessment and safety surveillance.
• Provide medical leadership and recommendations in data review meetings, safety review committees and cross-functional governance forums.
• Contribute to the clinical part of submission dossiers, including regulatory and safety documents, health authority responses and meetings, internal governance materials and external scientific communications.
• Support preparation of abstracts, posters, manuscripts and presentations for scientific meetings and publications.

External & Operational Excellence

• Provide medical and scientific leadership in interactions with investigators, CROs, vendors and external experts to support high-quality trial execution.
• Lead or support investigator meetings and training sessions.
• Ensure strict compliance with current regulations, laws, ICH-GCP, health authority guidance and Damora policies and procedures, and maintain inspection readiness for assigned studies.

What You Bring

• MD or equivalent medical degree with specialist training in hematology/oncology (strongly preferred), immunology or another relevant specialty. Board certification is preferred.
• 6 years of experience in clinical practice, research and/or drug development, in academic or industry settings.
• Demonstrated ability to serve as medical monitor independently, including eligibility and toxicity decisions and benefit-risk assessment with incomplete or evolving data.
• Strong scientific and clinical background in hematology, oncology or immunology is required. MPN experience is strongly preferred.
• Direct experience leading or supporting early-phase (Phase 1 / first-in-human) clinical trials is preferred.
• Expertise in clinical development and the methodology of clinical studies, and an understanding of pharmaceutical product development and life cycle management.
• Demonstrated ability to independently lead complex workstreams and influence cross-functional teams in a fast-paced biotech environment.
• Experience contributing to the development and authorship of clinical and regulatory documents.
• Strong analytical and scientific interpretation skills, including the ability to synthesize emerging clinical, safety and biomarker data into actionable insights.
• Excellent written and verbal communication skills, including with investigators, committees and key regulatory agencies.
• Strong leadership and collaboration abilities, including the capacity to inspire and guide cross-functional teams toward project and team goals.
• Fluent English, spoken and written.