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Information Security Engineers, Agentic AI

D. E. Shaw Research
York, NY Full Time
POSTED ON 10/23/2026
AVAILABLE BEFORE 12/22/2026

Exceptional information security engineers sought for a New York-based drug discovery and computational biochemistry research company. Successful hires will be responsible for developing and improving upon security processes for the company, evaluating and resolving potential threats and vulnerabilities, and implementing and managing automation to address common security issues. Securing agentic AI systems and workflows is a particular focus of our team. Opportunities are available in our New York City offices or our Durham, NC and Pittsburgh, PA data centers.
Ideal candidates will have strong knowledge of information security fundamentals, including threat detection and response, vulnerability management, penetration tests, common attack vectors, and endpoint detection and response. Relevant areas of expertise might include operational experience in DevSecOps, developing information security policies and procedures, deploying security tools, securing agentic AI systems and workflows, and automating the process of detecting and mitigating potential vulnerabilities, in addition to strong programming and scripting ability. Candidates should have excellent communication skills, and we will consider candidates at all levels of experience.
D. E. Shaw Research (DESRES), based in New York City, develops and uses advanced computational technologies to understand the behavior of biologically and pharmaceutically significant molecules at an atomic level of detail, and to design precisely targeted, highly selective drugs for the treatment of various diseases. Among its core technologies is Anton, a proprietary special-purpose supercomputer that DESRES designed and constructed to vastly accelerate the process of molecular dynamics simulation. DESRES uses Anton machines and high-speed commodity hardware, together with machine learning methods and other computational techniques, in both internal and collaborative drug discovery programs. For more information, visit www.DEShawResearch.com.
We are looking to add innovative contributors who share our commitment to fostering a stimulating, positive, and collaborative work environment.
To submit an application, please use the link provided below:
https://apply.deshawresearch.com/careers/Register?pipelineId=960&source=LinkedIn
The expected annual base salary for this position is $300,000–$1,000,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits, including relocation and immigration assistance. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience, educational background, and location. We follow a hybrid work schedule, in which employees work from the office on Tuesday through Thursday, and have the option of working from home on Monday and Friday.
D. E. Shaw Research, LLC is an equal opportunity employer.

Salary : $300,000 - $1,000,000

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