Scientist II Translational Immunology

Position Details

Industry: Biotechnology / Pharmaceutical Research
Job Title: Scientist II - Translational Immunology
Duration: 6 Months Contract
Location: Cambridge, MA 02139 - Hybrid
Work Schedule: Monday-Friday | 8:00 AM - 5:00 PM | 40 hours/week
Pay Range: $40.00 - $48.00 per hour 

Purpose

The Scientist II supports early discovery research within translational immunology by executing molecular biology and functional immunology experiments. This role focuses on RNA sequencing workflows, primary immune cell handling, and ligand-based assays to support target identification and validation. The scientist collaborates with cross-functional discovery teams to generate, analyze, and communicate high-quality experimental data in a fast-paced research environment.

Essential Requirements

• Hands-on experience with RNAseq workflows, including library preparation and quality control


• Experience handling PBMCs, primary human cells, and/or tissues


• Background in biology, immunology, molecular biology, or a related scientific discipline


• Experience performing ligand-based assays (e.g., ELISA, MSD, Luminex)

Nice to Have

• Experience with end-to-end bulk RNAseq library preparation and sequencing


• Familiarity with 10X Genomics platforms (scRNAseq and/or scATACseq)


• Experience with complex immune cell cultures and stimulation assays


• Exposure to R or other data analysis tools


• Prior immunology-focused research experience

Education

• Bachelor’s degree with typically 5 years of relevant experience, or


• Master’s degree with typically 2 years of relevant experience


• Degree in Biology, Immunology, Molecular Biology, Genomics, or a related field

Responsibilities

• Execute RNAseq library preparation and QC using instruments such as TapeStation and Qubit


• Prepare sequencing libraries and operate SBS platforms, including basic troubleshooting.


• Perform multiplexed ligand-based assays (e.g., Luminex)


• Conduct functional experiments using primary human immune cells, including stimulation and culture


• Perform routine molecular biology techniques such as DNA/RNA extraction and nucleic acid QC


• Accurately document experimental procedures, data, and samples in an Electronic Lab Notebook (ELN)


• Troubleshoot and optimize experimental protocols independently and collaboratively


• Interpret experimental data and communicate findings to internal scientific stakeholders


• Partner with computational biologists and data scientists to generate and interpret RNAseq datasets


• Support cross-functional discovery activities in a matrixed research environment

Required Skills

• Strong foundation in molecular biology and/or genomics


• Hands-on experience with RNAseq library preparation and QC workflows


• Experience handling primary immune cells and PBMCs


• Proficiency with ligand-based immunoassays (ELISA, MSD, Luminex)


• High attention to detail with strong documentation practices


• Ability to work independently while collaborating effectively across teams


• Strong written and verbal communication skills

Benefits:

The Company offers the following benefits for this position, subject to applicable eligibility requirements: medical insurance, dental insurance, vision insurance, 401(k) retirement plan, life insurance, long-term disability insurance, short-term disability insurance, paid parking/public transportation, (paid tim, paid sick and safe time, hours of paid vacation time, weeks of paid parental leave, paid holidays annually - These all are subject to applicable eligibility).